This book provides an in-depth description and discussion of different multi-modal diagnostic techniques for cancer detection and treatment using exact optical methods, their comparison, and combination. Coverage includes detailed descriptions of modern state of design for novel methods of optical non-invasive cancer diagnostics; multi-modal methods for earlier cancer diagnostic enhancing the probability of effective cancer treatment; modern clinical trials with novel methods of clinical cancer diagnostics; medical and technical aspects of clinical cancer diagnostics, and long-term monitoring. Biomedical engineers, cancer researchers, and scientists will find the book to be an invaluable resource.

• Introduces optical imaging strategies;
• Focuses on multimodal optical diagnostics as a fundamental approach;
• Discusses novel methods of optical non-invasive cancer diagnostics.

Introduction: Enhancing Detection and Early Cancer Recognition with Multimodal Optical Imaging and Spectral Analysis

Malignant tissue optics
Optical clearing of biological tissues: prospects of application for multimodal cancer diagnostics
Multiparametric analysis of tumor using microscopic fluorescence imaging
NIRS for brain cancer detection
Exhaled air analysis using wideband wave number tuning range infrared laser photoacoustic spectroscopy
Multispectral and multimodal fiber sensing in oncology
Diagnostics of pigmented skin tumors based on laser-induced autofluorescence and diffuse reflectance spectroscopy
Raman-based molecular imaging and analytics, Surface-enhanced Raman spectroscopy for cancer diagnostics, Raman/CARS/TPEF/SHG multimodal imaging as a pathological screening tool
In vivo Multimodal Optical Biopsy of Skin Cancer
Raman hyperspectroscopy and advanced statistics for cancer differentiation
Intraoperative brain cancer detection with Label-Free Multimodal Optical Spectroscopy
3D confocal Raman and two-photon microscopy imaging of the skin
Multimodal Optical Imaging for Cancer Detection
Multidimentional and Multilevel Imaging: towards 3D histopathology
Multimodal OCT for malignancy imaging
Multimodal texture analysis of OCT tumor images
Hyperspectral imaging and cancer detection
Multimodal Deep Imaging using SORS and OCT: for precise cancer boundary detection
FLIM imaging combined with MRI
Terahertz spectroscopy of human brain tumor.