The idea that the brain is an "immune-privileged site" has perhaps served to slow our realization that the intact brain can generate its own inflammatory reactions. These responses can be to peripheral infection, or they can arise from local, internal causes, for instance as a response to stress or to the se vere changes in neuronal activity in seizure or the loss of oxygen in stroke. We are also becoming increasingly aware of the contribution of local inflam matory reactions to certain neurodegenerative diseases such as Alzheimer's In fact, evidence is accumulating that inflammatory processes disease (AD). contribute to the progression of AD, suggesting the possibility of using cur rently available or novel anti-inflammatory agents to interfere with this terri ble disease. Correlations are also being made between inflammatory signs and mental illness, which is a new frontier of research. This book presents the current state of knowledge in a variety of areas relevant to neuro-immune interactions, with particular attention to AD.

Organization of Inflammatory Processes in Alzheimer's Disease

Glial Cytokines in Neurodegenerative Conditions
Contributions of the Glial Injury Response to the Multifactorial Pathogenesis of Alzheimer's Disease
Cytokine Communication Between Neurons and Glia and the Pathogenesis of Alzheimer's Disease
Glial Hyperactivity During Aging as a Neuroinflammatory Process
Mechanistic and Metaphorical Connections Between NF-KB and the Secreted Alzheimer's ?-Amyloid Precursor Protein
Pathological and Biochemical Studies of Chronic Neuroinflammation May Lead to Therapies for Alzheimer's Disease
Serotonine-Immune Interactions in Major Depression
Responses in the Raphe-Hippocampal Serotonergic System During Peripheral Inflammation: Putative Role in Sickness Behaviour
Neuronal Control of the Immune Response in the Central Nervous System: From Pathogenesis to Therapy
Regulation of Cyclic AMP Synthesis in Microglial Cells and Possible Role of Cyclic AMP in Neuroprotection
Cytokine and Anti-Inflammatory Drug Effects on Brain Trauma and Alzheimer's Disease Pathology in Transgenic Mice
In vivo Involvement of the Cytokine LIF During Lesion-Induced Renewal of Olfactory Sensory Neurons in Adult Mouse
Neuroglial Activation in the Nervous System Following Injury: Role of Cytokines
Sickness Behavior: A Neuroimmune-Based Response to Infectious Disease
Central Origin of IL-1? Produced During Peripheral Inflammation: Role of Meninges
Vitamin D, a Hormone Involved in the Control of Neuro-immune Interactions in the Brain.