This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson's disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.

Neurodegenerative Diseases is aimed at clinicians, particularly those workingin academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Role of Genetics and Epigenetics in neurodegenerative disorders of the central nervous system

Diagnosis and treatment of Alzheimer's Disease and atypical forms
Autosomal Dominant Alzheimer's Disease: Underlying Causes
Genetic Risk Factors for sporadic Alzheimer's Disease
The Role of Cerebrovascular Disease in Cognitive Decline
Environmental Risk Factors in Alzheimer's Disease and Mild Cognitive Impairment
Diagnosis of Frontotemporal dementia
Autosomal dominant Frontotemporal Lobar Degeneration: from genotype to phenotype
Genetic Risk Factors for sporadic Frontotemporal Dementia
Alzheimer's Disease and Frontotemporal Lobar Degeneration: Mouse Models
Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Frontotemporal Dementia
Biomarkers for Alzheimer's Disease and Frontotemporal Lobar Degeneration: Imaging
Amyotrophic Lateral Sclerosis: Genotypes and Phenotypes
Lewy Body dementia
Rare Dementias
Neurodevelopment Alterations, Neurodegeneration, and Immunoinflammatory Patterns in the Pathophysiology of Schizophrenia and bipolar disorders
Parkinson's disease
Neurodegeneration and Multiple Sclerosis.