Roughly one in every five patients referred to a neurologist suffers from headaches; the majority have migraines. Although headache specialists understand migraine on a clinical basis, the pathophysiological changes that provoke and accompany the development of a migraine attack continue to elude us.

Several decades have passed since the pioneering electroencephalographic study by Golla and Winter (1959), which underscored the role of abnormal rhythmic activities in migraine. Since then, there have been substantial advances in the field; a wealth of neurophysiological studies has enriched our understanding of the pathophysiological facets of the migraine pathology. Virtually every known technique of clinical electrophysiology has since been used to study the migraine brain and, more recently, new neurophysiological tools have been added to the arsenal. Nevertheless, applying the principles of peripheral and central neuromodulation offers a promising way to transfer the principles of synaptic plasticity to the patient's bedside.

This book belongs to the Headache Series endorsed by the European Headache Federation. Written by internationally recognized experts in their respective fields, it covers all aspects of clinical neurophysiological methods that represent significant advances in our understanding of the pathophysiology of migraine. It will offer a valuable toolkit for beginners, and a reference guide for experts.

Electroencephalography

2 Magnetoelectroencephalography
3 Evoked potentials
4 Cognitive potentials
5 Sleep and migraine
6 Brain oscillations and migraine
7 Brainstem reflexes
8 Spinal reflexes in migraine
9 Sensorimotor integration in migraine
10 Pain-related evoked potentials
11 Pain perception and migraine
12 The genetic basis of the neurophysiological findings
13 Neuromodulation for  evaluating the pathophysiology of migraine
14 Neurophysiology of migraine aura
15 Neurophysiology in children and elders with migraine
16 Neuroimaging correlates of neurophysiological findings
17 Neurophysiological model of migraine pathophysiology: bringing the past into to the future.