In 1988, for the first time in its thirty years history, the Collegium Interna tionale Neuropsychopharmacologicum (CINP) with one of its biannual congresses returned to the same city - to Munich. In Munich, 26 years ago (1962) the IIIrd CINP Congress had been held. A comparison of these two Munich CINP Congresses is evidence for the fruitful growing and expansion of research in basic and clinical neuropsychopharmacology. In 1988, more than 3000 people attended the XVIth CINP Congress. And it was necessary to have - besides poster presentations - up to fourteen parallel sessions. By decision of the Programme Committee (A. Coppen, E. Costa, H. Hippius, J. Mendlewicz, G. Racagni and I. Yamashita) 65 symposia to special topics had been accepted and were held during one week. These symposia were the core of the congress. Special scientific highlights of the congress were the four plenary sessions. There, lectures were presented by two Nobel Prize Laureates- G. Edelman and M. Eigen -and six other outstanding scientists (B. Sakmann and the CINP members W. E. Bunney, A. Carlsson, P. Janssen, M. Schou, G. Sedvall). With the aim to inform about the results of the XVIth CINP Congress as many scientists as possible, the CINP Executive Committee and the Pro gramme Committee published in a separate volume the abstracts of all symposium-presentations, all platform- and poster-presentations ("Psycho pharmacology" - Supplement to Volume 96 - Springer International 1988).

'1 Introduction

Perspectives on Dopamine as a Regulator of Brain Function
A View of Psychopharmacology, Neuroscience, and the Major Psychoses
Lithium Is All Right, but ... About Some Misconceptions and Some Recent Findings
Improvement in the Quality of Sleep: A New Goal in Psychopharmacology
The Future of Psychopharmacology and Positron Emission Tomography
2 Molecular Biology in Neuropsychopharmacology
Molecular Biological Approaches to Brain Region- and Cell-Specific Molecules
The ?1-Adrenergic Receptor as a Paradigm of Receptors Coupled to Guanine Nucleotide Binding Proteins
The Alpha-2 Adrenoceptor Vulnerability Hypothesis of Depression: From the Clonidine Growth Hormone Stimulation Test to the Genes Encoding a Human Alpha-2 Adrenoceptor and Phenylethanolamine N-Methyltransferase
3 Molecular Biology in Neurology and Psychiatry
Genetic Linkage Analysis in Early-Onset Familial Alzheimer's Dementia
Molecular Genetic Approach in Affective Illness
Molecular Genetic Studies in Affective Disorders
4 Brain Transplants in Neurology and Psychiatry
Long-Term Changes in Parkinson's Disease Patients with Adrenal Medullary Autografts to the Caudate Nucleus
5 Peripheral Cells as Pharmacological Models in Psychiatric Research
Lymphocyte Cholinergic Receptor Changes in Alzheimer's Disease
Increased Platelet Membrane Fluidity in Alzheimer's Disease: An Initial Assessment of Specificity
[3H] Spiperone Binding to Lymphocytes in Psychiatric Disorders
Platelet Binding Sites for Serotonin Uptake Inhibitors: Is [3H]Imipramine Binding Decreased in Depression?
Changes in Platelet Serotonergic and Adrenergic Function in Patients with Depression, Panic Attack, and Mania
Platelet Monoamine Receptor Binding and Tricyclic Antidepressant Treatment
6 Endogenous Ligands for Psychotropic Drug Receptors
Endogenous Opioids and Motivational Processes: Examination of the Neural Substrates Mediating Opioid-Induced Reward and Aversion
7 Biological Markers of Affective Disorders: Impact of Basic Neuroendocrine and Sleep Research
Sleep-Physiological Characteristics as Potential Biological Markers in Affective Disorders
Experimental Approaches for Testing the Cholinergic-Noradrenergic Imbalance Hypothesis of Affective Disorders
Cortisol Response to Corticotropin Releasing Hormone in Dexamethasone-Pretreated Patients with Depression
Differential Effects and Receptors of Corticosteroids in the Brain: Implications for Psychopathophysiology
Neuropeptides and Affective Disorder
Molecular Mechanisms Controlling Proopiomelanocortin Gene Expression
8 ?-Adrenoreceptors in Depression and for Antidepressant Effect
Antidepressant Drugs Given Repeatedly and ?1-Adrenoceptors
The Effect of Phenylethanolamine-N-Methyltransferase Inhibitor on Locomotor Activity in Rats: The Role of Central ?2-Adrenoceptor and PNMT Activity
Neuroendocrine Studies of ?2-Adrenoceptor Function and the Mechanism of Action of Antidepressant Drugs
Levoprotiline: Clinical Therapeutic Efficacy and Tolerability
?2-Adrenoceptor Interaction with Opiate Receptors
Influence of Psychotropic Drugs on Pituitary Hormone Secretion with Special Reference to Norepinephrine Reuptake Inhibition
9 The Thyroid Axis in Basic and Clinical Research
The TRH Test in Psychiatric Disorders
The Blunted TSH Response to TRH - What Does it Tell Us? Biological Monitoring During Psychopharmacological Treatment
Alcoholism and the Thyroid Axis
Marginal Hypothyroidism in Mental Illness: Preliminary Assessments of Prevalence and Significance
Antithyroid Antibodies: Behavioral Significance
The Simultaneous Use of Four Releasing Factors: Theoretical and Practical Issues
10 PET Imaging in Neurosciences and Psychiatry
Strategies for In Vivo Quantification of Human Neuroreceptors by Positron Emission Tomography
Positron Emission Tomography with [18F]Deoxy