This book provides a detailed overview of the activity and efficacy of new treatments and promising perspectives in the field of cutaneous malignancies. The first part of the book covers the basic molecular and immunological mechanisms. It then goes on to cover specific strategies in melanoma and non-melanoma skin cancers that, starting from the basic mechanisms, translate this information into clinical routine or translational research. 

This unique handbook comprises very practical structured descriptions of more than 10 new agents used in treatment of melanomas and skin carcinomas together with biological background of their mechanisms of action. It provides structured and up-to-date information about all therapeutics in cutaneous malignancies, making it extremely useful in clinical practice, for clinicians that need timely and focused information.

Prepared by a group of international authors from expert melanoma centres in Europe, the book provides knowledge distilled from the diverse perspectives of the contributing authors (pathologists, translational scientists and clinicians). This book is of interest to medical oncologists, oncological surgeons, dermatologists and immunologists as well as biologists and pharmacologists.

Part 1. Pathological, molecular and immunological background of Cutaneous Malignancies

Pathology of Melanoma and Skin Carcinomas
Molecular Landscape Profile of Melanoma
Molecular Landscape of Skin Carcinomas
Immunological Features of Melanoma
Part 2. Targeted Therapies in Skin Cancers
Dabrafenib and Trametinib
Vemurafenib and Cobimetinib
Encorafenib and Binimetinib
Vismodegib
Sonidegib
Part 3. Immunological Strategies in Advanced Melanoma
Ipilimumab
Nivolumab
Pembrolizumab
Talimogene Leharparepvec
Part 4. Future of Melanoma Immunotherapy
Perspectives of Immunotherapy in Advanced Melanoma Combinations and Sequencing
Part 5. Immunological Therapies in Advanced Skin Carcinomas
Avelumab
Cemiplimab
Perspectives of Immunotherapy in Non-Melanoma Skin Cancers
Part 6. Mechanism of Resistance to Therapy
Mechanisms of Resistance to Targeted Therapies in Skin Cancer
Mechanisms of Resistance to Immunotherapy
Part 7. Perioperative Therapy of Melanoma
Neoadjuvant and Adjuvant Therapy in Melanoma
Part 8. Special Techniques and Populations
Adoptive Cell Therapy Immunological Therapies in Special Populations: HIV, Hepatitis and Organ Transplantation
Conclusions.