This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch's role in the development of the embryo to the Notch signaling pathway's role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch's role in senescence, the regulation of Notch signaling by microRNAs, Notch's role in the microbiome, diet and its influence on Notch signaling and more.

Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling - this is a definitive discussion of the topic, presented by internationally-recognized contributors.  Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.

Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword.- Transcription factor RBPJ as a molecular switch in regulating the Notch response.- Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer.- Notch and endometrial cancer.- Notch and Esophageal Squamous Cell Carcinoma.- Notch signaling and liver cancer.- Notch inHead and Neck Cancer.- Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis.- The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond.- Notch Signaling in Thyroid Cancer.- The Relevance of Notch Signaling in Cancer Progression.- Notch Signaling and the Breast Cancer Microenvironment.- Notch pathway: a journey from notching phenotypes to cancer immunotherapy.- Index.