1;Foreword;5 2;Preface;6 3;Contents;7 4;Part I Nutrition and Skin: The Scientific Basis;9 4.1;1: Cutaneous Changes in Nutritional Diseases;10 4.1.1;1.1 Nutritional Deficiencies;10 4.1.1.1;1.1.1 Marasmus and Kwashiorkor;10 4.1.1.2;1.1.2 Essential Fatty Acid Deficiency;12 4.1.1.3;1.1.3 Vitamin Deficiencies;12 4.1.1.4;1.1.4 Trace Element Deficiencies;15 4.1.2;1.2 Excess Nutrition;17 4.1.2.1;1.2.1 Obesity;17 4.1.2.2;1.2.2 Hypervitaminoses;17 4.1.2.3;1.2.3 Trace Element Deposition;18 4.1.3;1.3 Abnormalities of Amino Acid Metabolism;18 4.1.4;1.4 Nutrition, Skin Physiology, and Skin Pathology;19 4.1.5;References;19 4.2; 2: Skin Aging;21 4.2.1;Core Messages;21 4.2.2;2.1 Introduction;21 4.2.3;2.2 Mechanisms of UV-Induced Photoaging;23 4.2.4;2.3 Mitochondrial DNA Mutations and Photoaging;23 4.2.5;2.4 Connective-Tissue Alterations in Photoaging: The Role of Matrix Metalloproteinases and Collagen Synthesis;25 4.2.6;2.5 UV-Induced Modulation of Vascularization;26 4.2.7;2.6 Photoaging as a Chronic Inflammatory Process;27 4.2.8;2.7 Protein Oxidation and Photoaging;27 4.2.9;2.8 Infrared a Radiation-Induced Retrograde Signaling;27 4.2.10;2.9 Concluding Remarks: The Defective Powerhouse Model of Photoaging of Human Skin;28 4.2.11;References;29 4.3;3: Non-melanoma Skin Cancer;31 4.3.1;Core Messages;31 4.3.2;3.1 General Overview;31 4.3.2.1;3.1.1 Skin Carcinogenesis;31 4.3.2.2;3.1.2 Protective Mechanisms of Carcinogenesis;32 4.3.2.3;3.1.3 Carcinogens of the Skin;32 4.3.3;3.2 Different Types of Non-melanoma Skin Cancer;33 4.3.3.1;3.2.1 Seborrheic Keratosis;33 4.3.3.2;3.2.2 Clear Cell Acanthoma;34 4.3.3.3;3.2.3 Dyskeratoma (Syn. "Warty Dyskeratoma");34 4.3.3.4;3.2.4 Actinic Keratoses;34 4.3.3.5;3.2.5 Bowen's Disease [6];34 4.3.3.6;3.2.6 Bowenoid Papulosis;34 4.3.3.7;3.2.7 Erythroplasia;35 4.3.3.8;3.2.8 Squamous Cell Cancer;35 4.3.3.9;3.2.9 Keratoacanthoma;35 4.3.3.10;3.2.10 Basal Cell Carcinoma;36 4.3.3.10.1;3.2.10.1 Clinical Subtypes;37 4.3.3.11;3.2.11 Prevention of UV-Induced Skin Cancer;37 4.3.3.12;3.2.12 Treatment of Non-melanoma Skin Cancer [11, 18, 21];37 4.3.3.12.1;3.2.12.1 Surgical Methods;38 4.3.3.12.2;Take Home Pearls;38 4.3.4;References;38 4.4;4: Skin Barrier Function;40 4.4.1;Core Messages;40 4.4.2;4.1 Overview of Barrier Function in Normal Skin;41 4.4.2.1;4.1.1 Cutaneous Barrier Function;41 4.4.2.2;4.1.2 Co-regulation and Interdependence of Permeability Barrier and Antimicrobial Defense;42 4.4.2.3;4.1.3 Stratum Corneum as a Dynamic Sensory Interface;43 4.4.2.4;4.1.4 External Stressors Alter Permeability Barrier Function;43 4.4.2.5;4.1.5 Sources, Function, and Pathophysiology of Stratum Corneum Acidification;44 4.4.2.5.1;4.1.5.1 Endogenous Sources of Stratum Corneum Acidification;44 4.4.2.5.2;4.1.5.2 Role of pH in Regulating Function;44 4.4.2.5.3;4.1.5.3 Pathophysiology of an Elevated Stratum Corneum pH;45 4.4.2.6;4.1.6 Permeability Barrier Function in Relation to Pigmentation;45 4.4.2.6.1;4.1.6.1 Enhanced Barrier Function in Darkly Pigmented Skin;45 4.4.2.6.2;4.1.6.2 Enhanced Epidermal Function of Darkly Pigmented Skin Correlates with a Lower SC pH;46 4.4.2.6.3;4.1.6.3 Lower pH of Melanocyte Dendrites Could Account for Lower pH of Pigmented Skin;46 4.4.3;4.2 Barrier Failure in Atopic Dermatitis;47 4.4.4;4.3 Basis for Abnormal Barrier Function in Atopic Dermatitis;48 4.4.4.1;4.3.1 Inherited Abnormalities;48 4.4.4.2;4.3.2 Acquired Stressors Could Further Aggravate Barrier Function in AD;49 4.4.5;4.4 "Outside-Inside," Then Back to "Outside" Pathogenic Mechanism in AD;49 4.4.6;4.5 A Potential New Therapeutic Paradigm for AD;50 4.4.7;References;51 5;Part II Functional Food for Skin Works: Intervention Studies in Humans and Animal Models;54 5.1;5: Botanical Antioxidants for Skin Protection: An Overview;55 5.1.1;Core Messages;55 5.1.2;5.1 Introduction;55 5.1.3;5.2 Green Tea/EGCG;56 5.1.4;5.3 Pomegranate;58 5.1.5;5.4 Resveratrol;59 5.1.6;5.5 Silymarin;60 5.1.7;5.6 Genistein;61 5.1.8;5.7 Curcumin;61 5.1.9;5.8 Sulforaphane;62 5.1.10;5.9 Lycopene;