How is growth controlled in normal cells? How are the growth control mechanisms perturbed in cancer cells? This book provides an up-to-date description of research aimed at resolving these questions. It is organized into four sections, each containing a series of short reviews written by experts in the field. The general headings are: growth factors, receptors, and related oncogenes: transduction of mitogenic signals and ras oncogenes; nuclear oncogenes and regulation of gene expression; and multiple steps involved in malignant transformation. The articles emphasize concepts rather than detailed facts and are intended not only for specialists in the field but also for interested readers, such as physicians and advanced students, who wish to stay abreast of developments in one of the most exciting fields in current biomedical research.

I Growth Factors and Proto-Oncogenes in Development and Differentiation

The Expression of Growth Factors and Growth Factor Receptors During Mouse Embryogenesis
A Role for Proto-Oncogenes in Differentiation?
Tissue-Specific Expression and Possible Functions of pp60c-src
II Growth Factors, Receptors, and Related Oncogenes
The Granulocyte-Macrophage Colony-Stimulating Factors
Role of PDGF-Like Growth Factors in Autocrine Stimulation of Growth of Normal and Transformed Cells
Transforming Growth Factor-?
Transforming Growth Factor-?
The Physiology of Epidermal Growth Factor
Structural Relationships Between Growth Factor Precursors and Cell Surface Receptors
Regulation of Cell Growth by the EGF Receptor
Mutational Analysis of v-erbB Oncogene Function
The c-fms Proto-Oncogene and the CSF-1 Receptor
Activation of the c-src Gene
Normal and Transforming N-Terminal Variants of c-abl
Transformation by the v-abl Oncogene
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Structure and Function of the Human Interleukin-2 Receptor
III Signal Transduction and ras Oncogenes
Phosphorylation in Signal Transmission and Transformation
Inositol Lipids and Cell Proliferation
Protein Kinase C
The Relevance of Protein Kinase C Activation, Glucose Transport, and ATP Generation in the Response of Haemopoietic Cells to Growth Factors
Cytoplasmic pH and Free Ca2+ in the Action of Growth Factors
Epidermal Growth-Factor Mediation of S6 Phosphorylation During the Mitogenic Response: A Novel S6 Kinase
Role of G Proteins in Transmembrane Signaling: Possible Functional Homology with the ras Proteins
The ras Gene Family
RAS Genes and Growth Control in the Yeast Saccharomyces cerevisiae
IV Gene Expression and Nuclear Oncogenes
Regulation of Human Globin Gene Expression
Regulation of GeneExpression by Steroid Hormones
Enhancers as Control Elements for Tissue-Specific Transcription
The Effect of DNA Methylation on DNA-Protein Interactions and on the Regulation of Gene Expression
Trans-Acting Elements Encoded in Immediate Early Genes of DNA Tumor Viruses
Transactivator Genes of HTLV-I, II, and III
Involvement of Proto-Oncogenes in Growth Control: The Induction of c-fos and c-myc by Growth Factors
Oncogenes and Interferons: Genetic Targets for Animal Cell Growth Factors
Regulation of c-myc Expression in Normal and Transformed Mammalian Cells
Properties of the myc and myb Gene Products
The fos Oncogene and Transformation
p53: Molecular Properties and Biological Activities
V Malignant Transformation as a Multistep Process
Oncogene Cooperativity in Stepwise Transformation of Rodent Embryo Fibroblasts by Polyoma Virus
Role of the Middle T: pp60c-src Complex in Cellular Transformation by Polyoma Virus
Oncogenes Cooperate, but How?
Individual and Combined Effects of Viral Oncogenes in Hematopoietic Cells
Multiple Factors Involved in B-Cell Tumorigenesis
Molecular Events Associated with Tumor Initiation, Promotion, and Progression in Mouse Skin
Amplification of Proto-Oncogenes and Tumor Progression
Suppression of the Neoplastic Phenotype
VI Oncogenesis in Transgenic Mice
Oncogenesis in Transgenic Mice.