Optical Polarization in Biomedical Applications

Optical Polarization in Biomedical Applications

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Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.


1;Preface;6 2;Contents;8 3;1 Introduction;11 3.1;1.1 Light Interaction with Tissues;11 3.2;1.2 Definitions of Polarized Light;13 4;2 Tissue Structure and Optical Models;16 4.1;2.1 Introduction;16 4.2;2.2 Continuous and Discrete Tissue Models;17 4.3;2.3 Scatterer Size Range and Distribution;18 4.4;2.4 Refractive-Index Variations and Absorption;20 4.5;2.5 Tissue Anisotropy;23 4.6;2.6 Volume Fraction and Spatial Ordering of Particles;27 4.7;2.7 Eye Tissue Optical Models;29 4.8;2.8 Fractal Properties of Tissues and Cell Aggregates;35 4.9;2.9 Summary;37 5;3 Polarized Light Interactions with Weakly Scattering Media;38 5.1;3.1 Introduction;38 5.2;3.2 Noninteracting Particles;39 5.3;3.3 Densely Packed Correlated Particles;45 5.4;3.4 Summary;51 6;4 Polarized Light Interactions with Strongly Scattering Media;53 6.1;4.1 Introduction;53 6.2;4.2 Multiple Scattering and Radiative Transfer Theory;54 6.3;4.3 Monte Carlo Simulation Technique;60 6.4;4.4 Densely Packed Particle Systems;69 6.5;4.5 Summary;75 7;5 Polarization Properties of Tissues and Phantoms;76 7.1;5.1 Introduction;76 7.2;5.2 Light Scattering Matrix Meters;77 7.3;5.3 LSM of Thin Tissue and Cell Layers;79 7.4;5.4 Strongly Scattering Tissues and Phantoms;84 7.5;5.5 Summary;90 8;6 Polarization-Dependent Interference of Multiply Scattered Light;92 8.1;6.1 Introduction;92 8.2;6.2 Coherent Backscattering;93 8.3;6.3 Polarization-Dependent Temporal Correlations of the Scattered Light;98 8.4;6.4 Polarization Microstatistics of Speckles;106 8.5;6.5 The Concept of Polarization-Correlation Universality;110 8.6;6.6 Summary;117 9;7 Decay of Light Polarization in Random Multiple Scattering Media;118 9.1;7.1 The Similarity in Multiple Scattering of Coherent Light;118 9.2;7.2 Influence of Scattering Anisotropy and Scattering Regime;126 9.3;7.3 Residual Polarization of Incoherently Backscattered Light;131 9.4;7.4 Polarization Decay in Absorbing Media;134 9.5;7.5 Summary;145 10;8 Degree of Polarization in Laser Speckles from Turbid Media;146 10.1;8.1 Introduction;146 10.2;8.2 Experiments and Simulation;147 10.3;8.3 Discussion and Conclusions;153 11;9 Monte Carlo Modeling of Polarization Propagation in Strongly Scattering Media;155 11.1;9.1 Introduction;155 11.2;9.2 Method;156 11.3;9.3 Results;158 11.4;9.4 Summary;165 12;10 Polarization-Sensitive Optical Coherence Tomography;166 12.1;10.1 Introduction;166 12.2;10.2 Experimental System: Serial Implementation;167 12.3;10.3 Jones Calculus and Mueller Calculus;169 12.4;10.4 Experimental System: Parallel Implementation;172 12.5;10.5 Experimental Results;177 12.6;10.6 Other Implementations;180 12.7;10.7 Summary;181 13;11 Biomedical Diagnostics and Imaging;182 13.1;11.1 Introduction;182 13.2;11.2 Imaging through Scattering Media and Tissues with Use of Polarized Light;182 13.3;11.3 Transillumination Polarization Techniques;186 13.4;11.4 Potentialities and Restrictions of Polarization Imaging with Backscattered Light;188 13.5;11.5 Polarized Reflectance Spectroscopy of Tissues;196 13.6;11.6 Glucose Sensing;197 13.7;11.7 Cytometry and Bacteria Sensing;204 13.8;11.8 Polarization Microscopy and Tissue Clearing;209 13.9;11.9 Digital Photoelastic Analysis;221 13.10;11.10 Fluorescence Polarization;223 13.11;11.11 Summary;228 14;A Appendix;229 14.1;Single-Scattering Mueller Matrix from Mie Theory;229 14.2;Coordinate Transformation in a Multiple Scattering Medium;230 14.3;Glossary;233 15;References;249 16;Index;283
ISBN 9783540453215
Artikelnummer 9783540453215
Medientyp E-Book - PDF
Copyrightjahr 2006
Verlag Springer-Verlag
Umfang 281 Seiten
Sprache Englisch
Kopierschutz Digitales Wasserzeichen