Main focus of the new book will be the description and discussion of rat and mouse models for organ transplantation. Various microsurgical techniques will be presented which allow transplantation of functional organs in syngeneic systems. In particular, the extremely difficult methods necessary for organ transplantation in mice will be presented and evaluated. Besides these practical aspects the book will also cover the theoretical sides of organ transplantation like the immunobiology of allotransplantation. Special emphasis will be given to the resurgent field of xenotransplantation. The results from xenograft models developed in the recent years using rats or mice will be reviewed and their impact on future human xenotransplantation will be discussed.

History and Development of Experimental Microsurgery

Organ Transplantation in Mice: Current Status and Future Prospects
Experimental Microsurgery as an Educational Concept and Scientific Basis for a Research Group: Principles of the Technical Development of Animal Models in Transplantation Research
Basic Requirements for Research with Small Rodents
Guidelines for the Use and Care of Small Laboratory Animals in Transplantation Research
Technical Aids and Training Program for Microsurgery
Statistical Methods in Small Animal Experimentation
In Vitro Analysis of Transplantation Experiments in Small Animals: Personal Experience and Practical Aspects
Basic Microsurgical Techniques for Rat Organ Transplantation
Microsurgical Techniques for Vascular Anastomoses: Suture and Cuff Technique
Heart Transplantation
Techniques of Skin, Renal, and Vascular Transplantation in the Rat
Microsurgical Techniques for Small Bowel Transplantation in Rats
Technique of Rat Islet Transplantation
Pancreas Transplantation in Rats
Combined Pancreas and Kidney Transplantation
Liver Transplantation
Lung and Thoracic Heart-Lung Transplantation
Combined Abdominal Organ Transplantation
Basic Microsurgical Techniques for Mouse Organ Transplantation...
Surgical Technique for Skin Transplantation in Mice
Surgical Technique for Vascularized Ear Transplantation in Mice
A Microsurgical Technique for Orthotopic Aorta Transplantation in Mice
Pancreatic Islet and Proislet Transplantation in the Mouse Model
Vascular Thymus Transplantation in Mice
Surgical Techniques for Mouse Heart Transplantation
Microsurgical Techniques for Kidney Transplantation in Mice
Microsurgical Techniques for Small Bowel Transplantation in Mice
Surgical Techniques for Orthotopic Liver Transplantation in Mice
Immunological Concepts and Techniques
Concepts and Mechanisms of Immune Activation, Graft Rejection, Immunosuppression, and Tolerance
Immunogenetic Basis of Organ Graft Rejection in Rat and Mouse
Oral Feeding and Intrathymic Injection of MHC Class I-derived Allopeptides Prolong Graft Survival
Microchimerism in Organ Transplantation
Gene Transfer and Tolerance Induction
Lessons from Knockout and Transgenic Mice
Immunological Methods in Small Animal Research
Analytical Methods in Molecular Biology
Vascular and Cardiac Transplantation in Rats
Venovenous Allotransplantation in the Rat
Segmental Femoral Artery Allografts: Histomorphological Analysis of the Rejection Response in Inbred Rat Strains
Chronic Rejection of Vascularized Organ Grafts in Rodent Models
Immunosuppression in Experimental Heart Transplantation
The Use of Rat Heterotopic Heart Transplantation Models to Characterize the Immunosuppressive Activities of Leflunomide
Lymphatic Reconstruction after Intestinal Transplantation in Rats
Small Bowel Transplantation
Immunological Phenomenon after Small Bowel Transplantation
Mucosal Immunology of the Small Bowel
Function Studies After Small Bowel Transplantation in the Rat
Methods and Effects of Immunosuppression After Small Bowel Transplantation in the Rat
Macrophage Depletion in Small Animal Transplant Models
Combined Liver and Small Bowel Transplantation - The Tolerogenic Effect on the Liver
Pancreas and Islet Transplantation in Rats
Immunological Basis of Pancreas Transplantation - Experimental Studies in the Rat
Immunosuppression After Pancreas Transplantation
Graft-Versus-Host Reaction After Pancreas Transplantation in the Rat
Management of Exocrine Secretion in Experimental Pancreas Transplantation in Rats
Results After Islet Transplantation in Rats
Alginate-Encapsulated Islets in Rats
Liver Transplantation in Rats
Orthotopic Liver Transplantation in the Rat: Survival Relationship Between Different Strain Combinations
Selective Immunosuppression After Orthotopic Rat Liver Transplantation with Monoclonal Antibodies Directed Against Adhesion Molecules and Activation Antigens
Biological Effect of Heterotopic Liver Transplantation
Immune Mechanisms of Liver Transplantation Tolerance in the Rat
Xenotransplantation
Experimental Concordant Xenografting in Small Animals
Reduction of Xenoreactive Antibodies by the Pharmacon Antigen Variation Effect in a Discordant Xenotransplantation Model
Technique of Plasmapheresis in the Xenogeneic Rat Model
Preconditioning Bone Marrow Transplants for Successful Xenotransplantation in the Small Animal Model
Transgenic Mouse Models and Knockout Mouse Models to Manipulate the Xenograft Response
Novel Mouse Models for Xenotransplantation Research
Transplantation Models in Human/Mouse Chimeras
Solid Organ Transplants in Mice
Development of Graft Vascular Disease in Transplanted Aortic Segments in Mice
Results of Heart Transplantation in Mice
Intestinal Transplantation in the Murine Model
Renal Allografts in the Mouse and Donor-Specific Tolerance Induced by Antibody to CD45RB
Donor-Specific Tolerance in Mouse Liver Transplantation.