Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that manifests with a myriad of clinical and laboratory features. The assessment of SLE is comprehensive and includes different core set domains; disease activity, damage, health-related quality of life, adverse events and economic impact. 

This comprehensive book is focused on the instruments and outcome measures utilized in the assessment of SLE. It targets different audiences including physicians, scientists/researchers and different health professionals interested in learning about the art of measurement in SLE. The book highlights the importance of measurement in the assessment of SLE in a clinical settings, research and clinical trials. Each of the chapters provide a systematic approach to the instruments utilized in the assessment of a specific construct in SLE (e.g., disease activity, fatigue, etc.) and incorporate a comprehensive coverage of disease specific and disease generic measures. Italso discusses different patient-reported outcomes that are crucial to reflect patient perceptions of their health condition and cover constructs such as fatigue, pain, anxiety and depression, cognition, frailty, and many others.

1. Introduction: Metrics and Psychometric Properties.- 2. Domains Measured in Systemic Lupus.- 3. Measuring Disease Activity.- 4. Measuring Damage.- 5. Measurements in Lupus Clinical Trials.- 6. Application of Measurements in Clinical Practice.- 7. Patient-reported Outcomes in Lupus.- 8. Health-related Quality of Life in Lupus.- 9. Assessment of Cognitive Function in Lupus.- 10. Assessment of Depression and Anxiety in Lupus.- 11. Assessment of Fatigue and Pain in Lupus.- 12. Emerging Concepts in Lupus: Sleep, Frailty, and Others.- 13. Activities and Participation for Patients with Lupus.