This book provides a comprehensive overview of the use of PET and SPECT in not only classic neurodegenerative disorders but also cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The new edition has been revised and updated to reflect recent advances and includes additional chapters, for example on the use of artificial intelligence and machine learning in imaging data analysis, the study of brain connectivity using PET and SPECT images, and the role of PET imaging in modulation of brain functioning by deep brain stimulation. The authors are renowned experts whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state of the art compendium will be invaluable for neurologists and radiologists/nuclear medicine specialists and will also be informative for interested general practitioners and geriatricians. Companion volumes on PET and SPECT in psychiatry and in neurobiological systems complete a trilogy.

PART I BASICS: Tracers for Neurology

Tracer-Kinetic Modeling
Quantification in Brain SPECT: Noninvasive Cerebral Blood Flow Measurements
Artificial Intelligence in the Analysis of PET scans of the Human Brain
MRI/PET Imaging of the Brain
The Default Network of the Brain
Analysis of Brain Connectivity using PET, SPECT, and MRI.- PART II DEMENTIA: Neuroimaging Findings in Dementia
Abeta Imaging
Imaging of Tau Pathology
Nicotinic Acetylcholine Receptors
Neuroimaging Findings in Mild Cognitive Impairment
Impact of the IWG/Dubois Criteria for AD in Imaging Studies
Perfusion SPECT in the Diagnosis of AD
Nuclear Imaging in Frontotemporal Dementia
Parkinson Dementia: PET Finding
SPECT/PET Findings in Lewy Body Dementia
Vascular Dementia
Value of MIBG in the Differential Diagnosis of Neurodegenerative Disorders.- PART III CEREBROVASCULAR DISORDERS: Perfusion Imaging in Healthy Human Ageing
Carotid Plaque Imaging with SPECT/CT and PET/CT
PET in Brain Arteriovenous Malformations and Cerebral Proliferative Angiopathy
PET Reveals Pathophysiology in Ischemic Stroke.- PART IV MOVEMENT DISORDERS: Parkinson's Disease
Computer-Aided Diagnosis of Parkinson Disease, Based on SPECT Scans of the Dopamine Transporter
PET and SPECT Imaging in Parkinsonian Syndromes
Amyotrophic Lateral Sclerosis
PET in Huntington Disease
PET and SPECT Imaging in Dystonia
PET and SPECT Imaging in Hyperkinetic Movement Disorders
Clinical Applications of FP-CIT SPECT.- PART V INFLAMMATORY DISORDERS: PET Imaging of Microglia Activation in Neuropsychiatric Disorders
PET Imaging in Multiple Sclerosis
PET and SPECT Imaging of Neurotoxicity
PET and SPECT in Hepatic and Uremic Encephalopathy.- PART VI EPILEPSY: PET in Epilepsy
Neuroimaging of Epilepsy
SISCOM: Subtraction Ictal SPECT Coregistered to MRI.- PART VII TUMORS OF THE NERVOUS SYSTEM: Gliomas
Neuro-SPECT of Brain Tumors
Methionine-PET to Distinguish Tumor Recurrence from Radionecrosis
Brain Metastases of Neuroendocrine Tumors
PART VIII OTHER SUBJECTS: Anesthesia and PET of the Brain
Altered States of Consciousness: Coma, Sleep and Hypnosis
Modulation of CNS Functions by Deep Brain Stimulation: Insights Provided by Molecular Imaging
Imaging in Pediatric Neurology.