PET and SPECT of Neurobiological Systems
PET and SPECT of Neurobiological Systems
This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, beta-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuableto all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.
PART I BASICS: Animal Models for Brain Research.- Small Animal Molecular Imaging - miPET, miSPECT
Cerebral Glucose Metabolism.- Cerebral Blood Flow Measurement with 15O-Water PET
Principles of Brain Perfusion SPECT
The Impact of Genetic Polymorphisms on Neuroreceptor Imaging
PART II SYSTEMS: Acetylcholinesterase
Adenosine Receptors
Beta-Amyloid and Other Proteinopathies
Central Benzodiazepine Receptors
Cyclooxygenase-2
Dopamine System in Humans
Endocannabinoid System
Glutamate Receptors (Metabotropic)
Histamine H3 Receptors
Hormone Receptors (Steroids)
Monoamine Oxidase B
MRP1 Function in the BBB
Neuroinflammation: From Target Selection to Preclinical and Clinical Studies
Nicotinic Acetylcholine Receptors
NMDA Receptors
Norepinephrine Transporter
Opioid Receptors
P-Glycoprotein and Other ABC Transporters
Phosphodiesterases
Purinergic Receptors
Serotonin System
Serotonin Transporter and Monoamine Oxidase A
Sigma-1 Receptors
Sigma-2 Receptors
Synaptic Density (SV2A)
Tau Pathology
Translocator Protein.- Tropomyosin Receptor Kinase
Vesicular Acetylcholine Transporter
Vesicular Monoamine Transporter.
Dierckx, Rudi A.J.O.
Otte, Andreas
de Vries, Erik F.J.
van Waarde, Aren
Lammertsma, Adriaan A.
| ISBN | 978-3-030-53175-1 |
|---|---|
| Artikelnummer | 9783030531751 |
| Medientyp | Buch |
| Auflage | 2. Aufl. |
| Copyrightjahr | 2020 |
| Verlag | Springer, Berlin |
| Umfang | XII, 1132 Seiten |
| Abbildungen | XII, 1132 p. 374 illus., 165 illus. in color. With Guest-Editor: tbc. |
| Sprache | Englisch |
