This volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in different tissues and in inflammatory and neuropathic pain states, and the contribution of proteinase activated receptors (PAR) to the development of pain in several chronic pain conditions. Chapters on nociceptive mechanisms in the spinal cord address the particular role of NO and of glial cell activation in the generation and maintenance of inflammatory and neuropathic pain and it discusses the potential role of local inhibitory interneurons, of the endogenous endocannabinoid system and the importance of non-neuronal immune mechanisms in opioid signaling in the control of pain. Furthermore, it is presented how spinal mechanisms contribute to the expression of peripheral inflammation.

Emerging concepts of pain therapy based on neuronal mechanisms

The pharmacology of nociceptor priming
Sodium channels and pain
Role of nerve growth factor in pain
Central sensitization in humans - assessment and pharmacology
The role of NO in the spinal cord
The role of the endocannabinoid system in pain
The role of glia in the spinal cord in neuropathic and inflammatory pain
Plasticity of inhibition in the spinal cord
Gene regulation in nociception. Modulation of peripheral inflammation by the spinal cord
The relationship between opioids and cytokines in the spinal cord
The role of proteases in pain. Pain-related pharmacology in the amygdala
Pain and itch - differences and commonalities.