Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles; .
Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles; .
This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon-carbon bonds in high atom- and step-economy.
In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, andhighlights its synthetic utility.
Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C-H activation and pi-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.
Chapter 1. Carbohalogenation Catalyzed by Palladium and Nickel
Chapter 2. Diastereoselective Pd-Catalyzed Aryl Cyanation and Aryl BorylationChapter 3. Pd-Catalyzed Spirocyclization via C-H Activation and Benzyne/Alkyne Insertion.
Yoon, Hyung
| ISBN | 978-3-030-54076-0 |
|---|---|
| Artikelnummer | 9783030540760 |
| Medientyp | Buch |
| Auflage | 1st ed. 2020 |
| Copyrightjahr | 2020 |
| Verlag | Springer, Berlin |
| Umfang | XXIX, 212 Seiten |
| Abbildungen | XXIX, 212 p. 552 illus., 35 illus. in color. |
| Sprache | Englisch |
