This book is a collection of case-based questions, directed towards and meticulously selected to cover the most common and important aspects of pediatric autoimmune disorders. Autoimmune disorders of infancy and childhood, rheumatological disorders, dermatologic autoimmune disorders, autoinflammatory disorders, and clinical immunology in solid organ and hematopoietic stem cell transplantation are among the topics covered.

 Each chapter starts with a case description followed by a series of 5-6 multiple choice questions (MCQ), presenting the flow from diagnosis to treatment in a step-wise, logical manner. The text guides the reader through the stream of real clinical practice from initial presentation, differential diagnosis, next best step, lab data, and definitive diagnosis to management and adverse effects of therapy. This MCQ format along with precise, yet detailed answer ensure a quick, reality learning to the reader.

 The book provides a quick guide and hands-on learning experience for pediatricians, hematologists, immunologists, transplant specialists, pulmonologists, as well as PhD and post-graduate researchers around the world.

Introduction to Autoimmunity, Secondary Immunodeficiency, and Transplantation-Fever and Cervical Lymphadenopathy-Prolonged Refractory High Fever-Pain in Both Knees-Challenging Pain in Knee and Ankle-Fever and Urticarial Rash-Knee Swelling and Rash-Malaise, Weight Loss and Intermittent Fever-Anemia, Microhematuria and Proteinuria-Fever, Anasarca and Arthralgia-Bradycardia in a Neonate-Annular Rash in a Neonate

Itchy Facial Rash
Muscle Weakness and Fever-Pruritic Erythematous Rashes on Face and Eyelids-Edema of Hands and Hypopigmented Lesions on Her Neck and Cheeks-Asymptomatic Atrophic Plaque on the Face-Morbiliform Rash and Fever-Recurrent Interstitial Keratitis and Audiovestibular Dysfunction-Breathlessness and Weight Loss
Neck Swelling and Fever
Puffy Face and Abdominal Distension
Hematuria and Abdominal Mass-Pitting Edema and Desquamation-Fever and Cutaneous Nodules
 Neck Stiffness and Fever-Rash and Generalized Body Pains-Positive HIV and Violet Macular Rash-Weight Loss and Tuberculin Skin Test Anergy-Edema on Lower Limbs-Asthenia and Fatigue-Infections, Whitish Skin Papules and Subcutaneous Nodules-Recurrent Pneumonia and History of Transplantation-Painful Skin Nodules, Prolonged Fever and Cervical Lymphadenopathy-Malaise, Laryngitis and Fever-Acute Myeloid Leukemia Requiring Hematopoietic Stem Cell Transplantation
Acute Myeloid Leukemia Requiring Hematopoietic Stem Cell Transplantation-Suspected Immunodeficiency
Acute Myeloid Leukemia Requiring Hematopoietic Stem Cell Transplantation
T-Lymphoblastic Lymphoma
No Lymphocytes in an Infant
DOCK8 Deficiency and No Matched Donor
Diarrhea Post-HSCT
Follow-Up of a Severe Combined Immunodeficiency, Who Received Bone-Marrow-Transplantation Four Decades Ago
Nonalcoholic Steatohepatitis Referred for Liver Transplantation
Acute Respiratory Distress during Stem Cell Infusion
Acute Dyspnea after Platelet Transfusion-Requiring Immunization after Rescue Autologous HSCT-Fever and Abdominal Pain-Prolonged Fever, Rash and Mucosal Bleeding-Recurrent Infections, Diarrhea and Hypereosinophilia-Liver Transplantation Who Developed Pancytopenia Post-Transplantation-Kidney Transplant Candidate Showing Presence of Pre-Formed Donor-Specific-Antibodies Against a Prospective Living Donor
Heart Transplant Candidate Who Required Extra-Corporal Membrane-Oxygenation (ECMO)-Acute Antibody-Mediated Rejection (AMR) Transplantation with Negative-Prospective Crossmatch Results-Kidney Transplantation in a Patient with End Stage Renal Disease (ESRD)-Secondary to Focal Segmental Glomerulosclerosis-Itchy Violaceous Plaques
Photosensitivity and Bullous Lesions-Recurrent Bullous Lesions-Refractory Blisters and Erosions-Annular Blisters and Erosions-Vesicular Pruriginous Lesions
Widespread Vesiculobullous Rash-Itchy Skin Rashes
Blisters on Back and Upper Extremities-Itchy Blisters-Sudden Onset Grouped Blisters-Pruritic Blisters
Widespread Depigmented and Hypopigmented Patches
Whitish Patches
Hyperpigmented Patches-Outbreaks of Erythematous and Necrotic Papules with Hemorrhagic Crusts
Persistant, Annular Urticarial Plaque
Yellow, Reddish Brown Skin Lesions
Erythroderma
Erythematous Scaly Plaques
Multiple Circinate, Sterile, Flaccid, Relapsing Pustules
Purpuric Macules and Oral Erosions
Diffuse Skin Rash and Mucosal Lesions
Painful Facial Ulceration
Patchy Hair Loss
Concerning Weight Loss Over Three Weeks
Toddler with Bruising on Knees.