This comprehensive clinical handbook for nurses in pediatric hematology/oncology, authored by nurse experts from the United Kingdom and North America, contains in-depth information regarding pathophysiology, diagnosis, treatment, advanced assessment, and interventions. The book is divided into 5 sections: pediatric cancers, hematologic disorders, treatment of childhood cancer, side effects of treatment and disease, and supportive and palliative care. It is organized in a user-friendly format with quick reference guides for the nurse. With the ongoing, challenging developments faced during the clinical nursing care of children with cancer, this handbook will provide an indispensable tool for those working in this speciality.

Written for:
Pediatric oncology nurses, pediatric hematology nurses, pediatric nurses, nursing educators, nursing faculty

Keywords:
advanced practice nursing
pediatric hematology
pediatric nursing
pediatric oncology

1;Dedication;6 2;Preface;8 3;Contributors;10 4;Contents;12 5;PART I;24 5.1;Chapter 1 Leukemia;24 5.1.1;1.1 Acute Lymphoblastic Leukemia;25 5.1.2;1.2 Acute Myeloid Leukemia;39 5.1.3;1.3 Chronic Myeloid Leukemia;43 5.1.4;1.4 Juvenile Myelomonocytic Leukemia;44 5.1.5;1.5 Langerhans Cell Histiocytosis;45 5.1.6;References;46 5.2;Chapter 2 Solid Tumors;48 5.2.1;2.1 Hodgkin's Disease;49 5.2.2;2.2 Non-Hodgkin's Lymphoma;53 5.2.3;2.3 Ewing's Sarcoma Family of Tumors;60 5.2.4;2.4 Osteosarcoma;64 5.2.5;2.5 Liver Tumors;68 5.2.6;2.6 Neuroblastoma;73 5.2.7;2.7 Renal Tumors;80 5.2.8;2.8 Retinoblastoma;85 5.2.9;2.9 Rhabdomyosarcoma;89 5.2.10;2.10 Non-rhabdomyosarcomatous Soft Tissue Sarcomas;94 5.2.11;2.11 Germ Cell Tumors;96 5.2.12;2.12 Rare Tumors;100 5.2.13;References;102 5.2.14;Bibliography;105 5.3;Chapter 3 Common Central Nervous System Tumors;108 5.3.1;3.1 Causes/Epidemiology;109 5.3.2;3.2 Distribution/Classification;109 5.3.3;3.3 Staging;110 5.3.4;3.4 Molecular Genetics of Brain Tumors;110 5.3.5;3.5 Diagnosis;110 5.3.6;3.6 Specialist Referral;112 5.3.7;3.7 Hydrocephalus;112 5.3.8;3.8 Treatment;112 5.3.9;3.9 Prognosis;114 5.3.10;3.10 Specific Tumors;115 5.3.11;3.11 Follow-up;123 5.3.12;3.12 The Late Effects and Rehabilitation of Survivors;123 5.3.13;3.13 Palliative Care;123 5.3.14;3.14 Future Perspectives/New Innovations;123 5.3.15;References;124 5.3.16;Bibliography;124 6;PART II;126 6.1;Chapter 4 Anemias;126 6.1.1;4.1 Anemia;127 6.1.2;4.2 Iron Deficiency Anemia;129 6.1.3;4.3 Sickle Cell Disease;132 6.1.4;4.4 Thalassemia;141 6.1.5;4.5 Hemolytic Anemia;144 6.1.6;4.6 Bone Marrow Failure Syndromes;149 6.1.7;References;153 6.2;Chapter 5 Neutropenia;157 6.2.1;5.1 Epidemiology;157 6.2.2;5.2 Etiology;158 6.2.3;5.3 Symptoms and Clinical Signs;159 6.2.4;5.4 Diagnostic Testing;159 6.2.5;5.5 Treatment;159 6.2.6;5.6 Prognosis;161 6.2.7;5.7 Follow-up;161 6.2.8;Reference;161 6.2.9;Bibliography;161 6.3;Chapter 6 Thrombocytopenia;163 6.3.1;6.1 Epidemiology;163 6.3.2;6.2 Etiology;164 6.3.3;6.3 Symptoms and Clinical Signs;164 6.3.4;6.4 Diagnostic Testing;166 6.3.5;6.5 Treatment;167 6.3.6;6.6 Prognosis;168 6.3.7;6.7 Follow-up;169 6.3.8;6.8 Future Perspectives;169 6.3.9;References;169 6.3.10;Bibliography;169 6.4;Chapter 7 BleedingDisorders;171 6.4.1;7.1 Hemophilia --- Nicole M. Sevier;171 6.4.2;7.2 Von Willebrand Disease;178 6.4.3;References;183 7;PART III;184 7.1;Chapter 8 Chemotherapy;184 7.1.1;8.1 Introduction;185 7.1.2;8.2 Chemotherapy Principles;185 7.1.3;8.3 Clinical Trials;188 7.1.4;8.4 Types of Chemotherapy Agents;188 7.1.5;8.5 Administration of Chemotherapy Agents;192 7.1.6;8.6 Routes of Administration and Practice Considerations;197 7.1.7;8.7 Safe Practice Considerations;201 7.1.8;8.8 Administration of Chemotherapy in the Home;204 7.1.9;8.9 Extravasation;207 7.1.10;8.10 Acute Hypersensitivity Reactions to Chemotherapy;212 7.1.11;References;214 7.1.12;Bibliography;215 7.2;Chapter 9 Radiation Therapy;217 7.2.1;9.1 Principles of treatment;217 7.2.2;9.2 Description of treatment;218 7.2.3;9.3 Methods of delivery;218 7.2.4;9.4 Potential side effects;220 7.2.5;9.5 Special considerations;221 7.2.6;9.6 Future Perspectives;222 7.2.7;References;222 7.3;Chapter 10 Hematopoietic Stem Cell Transplantation;223 7.3.1;10.1 Principles of Treatment;223 7.3.2;10.2 Description of Treatment;226 7.3.3;10.3 Potential Side Effects;229 7.3.4;10.4 Special Considerations;237 7.3.5;10.5 Future Perspectives;238 7.3.6;References;238 7.3.7;Bibliography;238 7.4;Chapter 11 Surgical Approaches to Childhood Cancer;242 7.4.1;11.1 Principles of Treatment;242 7.4.2;11.2 Description of Treatment;242 7.4.3;11.3 Method of Delivery;243 7.4.4;11.4 Potential Side Effects;245 7.4.5;11.5 Special Considerations;246 7.4.6;11.6 Future Perspectives;247 7.4.7;References;248 7.4.8;Bibliography;248 7.5;Chapter 12 Gene Therapy;249 7.5.1;12.1 Introduction;249 7.5.2;12.2 Principles of Treatment;250 7.5.3;12.3 Method of Delivery;251 7.5.4;12.4 Potential Side Effects;252 7.5.5;12.5 Special Consideration