This second fully updated and extended edition of the textbook serves as a highly readable guide on latest developments in vaccine development and vaccination programs in infants, children and adolescents from a European perspective. The first part of the book introduces to general vaccinology, immunization programs and formulation, effects and unwanted effects of vaccines. The second and third part provide an overview on current viral and bacterial vaccines. The fourth and last part of this book discusses new vaccines in the pipeline and gives insights into safety and regulatory matters. 

This second edition is extended by a whole new chapter on COVID-19 vaccines.

This book serves as a reference textbook in the field and helps to standardize the information on vaccines and immunization programs in the WHO European Region.

Part 1 General Vaccinology

1 Expected and Unexpected Effects of Vaccination
2 How Vaccinating People Can Also Protect Others
3 Childhood and Adolescent Immunization Programs in Europe
4 Vaccine Hesitancy, Acceptance, and Demand
5 Adjuvants in Pediatric Vaccines
6 Maternal Immunization
7 Neonatal Immunization
Part 2 Viral Vaccines and Vaccinations
8 Poliovirus Vaccines
9 Measles-Mumps-Rubella Vaccine
10 Varicella Vaccines
11 Rotavirus Vaccine
12 Hepatitis A Vaccines
13 Hepatitis B Vaccines
14 Influenza Vaccines
15 Human Papillomavirus Vaccines
16 Tick-Borne Encephalitis Vaccines
Part 3 Bacterial Vaccines and Vaccination
17 Tuberculosis Vaccines
18 Pertussis Vaccines
19 Haemophilus influenzae type b (Hib) Vaccines
20 Pediatric Combination Vaccines
21 Pneumococcal Vaccines
22 Meningococcal Vaccines
23 Pediatric Vaccines for Travel Outside Europe
Part 4 New Vaccines in Pipeline Development
24 GBS and CMV Vaccines in Pipeline Development
25 Norovirus Vaccines in Pipeline Development
26 RSV Vaccines and Monoclonal Antibodies in Development
27 COVID-19 in Children and COVID-19 Vaccines
28 Registration of Vaccines, Safety Follow-Up, and Pediatric Investigation Plan.