Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods - both well established and recently introduced - in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.

From the contents: THE ROLE OF SKIN HYDRATION IN PENETRATION ENHANCEMENT

CHEMICAL PENETRATION ENHANCERS IN PENETRATION ENHANCEMENT.-Classification
Mechanism
Structure-Activity Relationship
The Microenvironment Of The Enhancer Site Of Action
Sulphoxides And Similar Chemicals
Iminosulfuranes
Azone And Azone Analogues
Fatty Acids, Fatty Acid Esters And Fatty Alcohols
Alcohols And Glycols
Terpenes And Essential Oils
Transcutol Surfactants
Nonionic Surfactants
Natural Surfactants Of The Alkylpolyglucoside Type
Sucrose Esters
Pyrrolidones
Chitosan
Urea And Its Derivatives
Transcarbams
Amines And Amides
Peptides
Synergistic Effects
CHEMICAL METHODS FOR TRANSDERMAL DELIVERY OF PEPTIDES AND PROTEINS
Ultradeformable Vesicles
Biphasic Vesicles For Transdermal Delivery Of Proteins
CHEMICAL METHODS IN CUTANEOUS VACCINATION
Vesicular Carriers In Transcutaneous DNA Vaccination
Nanoparticles And Microparticles For Transcutaneous DNA Vaccination
Chitosan-Nanoparticles In Gene Delivery.