In spite of a "war on drugs" that spans years, and in spite of increases in law enforcement efforts and to a lesser extent treatment, substance abuse and dependence continue. While the number of people who experiment with drugs has decreased in recent years, those who use drugs repeatedly, per haps several times a week, a measure of "hard core" drug abusers, has not changed, and emergency room visits associated with substances abuse continues to rise. Considering both licit and illicit drug abuse, the number of drug abusers in, for example, the United States is very large and, accordingly, the cost to society is great. A recent Institute of Medicine study suggests that the overall cost is about $66 billion per year (1990 costs). Certainly when assessing the total cost of substance abuse, we must include of the costs of disease and behavioral disorders that are intimately associated with substance abuse. For example, sharing of needles among illicit drug abusers has been and is a critical vector in the spread of drug resistant TB, AIDS, and hepatitis. Further, the use of drugs and alcohol leads to unsafe sexual practices with the attendant risk of AIDS and other sexually transmitted diseases. Tragically, infants are born with drugs in their system and with infections and disease transmitted from the mothers who are drug abusers or their sex partners who are drug abusers.

I. Research in the Study of Drug Action and Addiction

1 Genetic Vulnerability to Substance Abuse
2 Integrative Neurobehavioral Pharmacology: Focus on Cocaine
II. Molecular, Behavioral, and Human Pharmacology of Dependence and Consequences
3 Marihuana
4 Cocaine
5 Opioid Analgesics
6 Phencyclidine: A Drug of Abuse and a Tool for Neuroscience Research
7 Benzodiazepine Discontinuation Syndromes: Clinical and Experimental Aspects
8 Nicotine
9 Caffeine Reinforcement, Discrimination, Tolerance and Physical Dependence in Laboratory Animals and Humans
10 Classical Hallucinogens
11 Alcohol
III. Advances in the Pharmacotherapy of Addiction
12 Pharmacotherapy of Addiction: Introduction and Principles
13 Development of Medications for Addictive Disorders
14a Long-Term Pharmacotherapy for Opiate (Primarily Heroin) Addiction: Opioid Agonists
14b Long-Term Pharmacotherapy for Opiate (Primarily Heroin) Addiction: Opioid Antagonists and Partial Agonists
15 Pharmacotherapy of Nicotine Dependence
16 Pharmacotherapies for Cocaine Dependence.