This contributed volume discusses the most important physiological aspects of phosphate metabolism, and how its pathological dysregulation can induce organ damage, which includes but is not limited to blood vessels, kidney, bone and tumor. The editor has selected a varied group of world renowned experts to provide a basic understanding of normal phosphate regulation, to then move on to explain the complex molecular mechanisms of abnormal phosphate regulation, also shedding some light on the downstream clinical consequences owing to phosphate toxicity. Each chapter clearly presents the biochemically important problems related to phosphate dysregulation with the necessary illustrations.

Readers will be able to use the proposed book as a quick reference for updated information on phosphate metabolism, ranging from cellular system to physiology, from pathology to toxicity, also including the associated clinical consequences, without much prior acquaintance with the field.

Mohammed S. Razzaque is currently a Professor of Pathology at the Lake Erie College of Osteopathic Medicine at Erie, Pennsylvania (U.S.A.). He obtained a Doctorate (Ph.D.) in pathology from Nagasaki University (Japan) and holds a degree in medicine (M.B.B.S.) from Chittagong University (Bangladesh). Dr. Razzaque is a Visiting Professor of Department of Oral Health Policy & Epidemiology at the Harvard School of Dental Medicine (U.S.A.), International Kazakh-Turkish University (Kazakhstan), University of Antwerp (Belgium), Al-Farabi Kazakh National University (Kazakhstan), and an Honorary Professor at the University of Rwanda College of Medicine & Health Sciences (Rwanda). He also worked as a Professor of Pathology at the Saba University School of Medicine (Dutch Caribbean) and as an Assistant Professor of Oral Medicine at the Harvard School of Dental Medicine. His research has focused on understanding phosphate regulation in health and disease, and his clinical interest is renal pathology. Dr. Razzaque is a recipient of an R01 grant as a Principal Investigator from the National Institute of Health (U.S.A.).