1;Preface;9 2;Contents;11 3;Part A Physical Aspects of QCM- Measurements;13 3.1;Interface Circuits for QCM Sensors;14 3.1.1;1 Introduction;17 3.1.2;2 Crystals;18 3.1.3;3 Fundamentals of Oscillators;33 3.1.4;4 Sensor Interface Circuits;38 3.1.5;5 Examples for Sensor Interface Circuits;44 3.1.6;References;57 3.2;Studies of Viscoelasticity with the QCM;59 3.2.1;1 Introduction;62 3.2.2;2 Complex Resonance Frequencies;66 3.2.3;3 Assumptions of the Standard Model;69 3.2.4;4 Wave Equations and Continuity Conditions: The Mathematical Approach;71 3.2.5;5 The QCM as an Acoustic Reflectometer: The Optical Approach;75 3.2.6;6 Equivalent Circuits: The Electrical Approach;79 3.2.7;7 Relation Between the Frequency Shift and the Load Impedance;85 3.2.8;8 Layered Systems within the Small-Load Approximation;88 3.2.9;9 Perturbation Analysis;103 3.2.10;10 Concluding Remarks;109 3.2.11;Appendix A Derivation of the Butterworth-van Dyke Equivalent Circuit;110 3.2.12;References;117 3.3;Probing the Solid/Liquid Interface with the Quartz CrystalMicrobalance;120 3.3.1;1 Introduction;122 3.3.2;2 Effect of Thin Surface Films;126 3.3.3;3 Quartz Crystal Operating in Contact with a Liquid;129 3.3.4;4 Quartz Crystals with Rough Surfaces Operating in Liquids;139 3.3.5;5 Slippage at Rough Surfaces;152 3.3.6;6 Conclusion;154 3.3.7;References;156 3.4;Studies of ContactMechanics with the QCM;159 3.4.1;1 Introduction;160 3.4.2;2 Modeling with Discrete Mechanical Elements;161 3.4.3;3 Nonlinear Mechanics and Memory Effects;169 3.4.4;4 Continuum Models;172 3.4.5;5 Concluding Remarks;176 3.4.6;References;177 4;Part B Chemical and Biological Applications of the QCM;179 4.1;Imprinted Polymers in Chemical Recognition forMass- Sensitive Devices;180 4.1.1;1 Introduction;181 4.1.2;2 Mass-Sensitive Devices;182 4.1.3;3 Generating Selectivity;190 4.1.4;4 Exemplary Sensor Applications;195 4.1.5;5 Future Outlook and Perspective;214 4.1.6;References;215 4.2;Analytical Applications of QCM- based Nucleic Acid Biosensors;218 4.2.1;1 Introduction;218 4.2.2;2 DNA-Based QCM Sensors Based on the Hybridization Reaction;220 4.2.3;3 Application of QCM Sensors Based on the Hybridization Reaction;225 4.2.4;4 New Frontiers in Nucleic Acid-Based Piezoelectric Biosensors: Aptasensors;235 4.2.5;5 Conclusions;239 4.2.6;References;240 4.3;Piezoelectric Immunosensors;243 4.3.1;1 General Introduction;244 4.3.2;2 Piezoelectric Immunosensors;261 4.3.3;References;281 4.4;Specific Adsorption of Annexin A1 on Solid Supported Membranes: AModel Study;287 4.4.1;1 Solid Supported Membranes;288 4.4.2;2 Interaction of Annexin A1 with Membranes;294 4.4.3;3 Conclusions;306 4.4.4;References;307 4.5;The Quartz Crystal Microbalance in Cell Biology: Basics and Applications;309 4.5.1;1 QCM as an Emerging Tool in Cell Biology;310 4.5.2;2 Lessons from Cell Adhesion;312 4.5.3;3 Analyzing Confluent Cell Layers;323 4.5.4;4 Electrochemical QCM: New Options and New Insights;338 4.5.5;5 Outlook on QCM Applications in Cell Biology;341 4.5.6;References;343 5;Part C Applications Based on Advanced QCM- Techniques;345 5.1;Enzyme Reactions on a 27 MHz Quartz CrystalMicrobalance;346 5.1.1;1 Introduction;346 5.1.2;2 Enzyme Reactions on DNA;348 5.1.3;3 Enzyme Reactions on Glycans;359 5.1.4;4 Conclusions;372 5.1.5;References;372 5.2;The Quartz Crystal Microbalance and the Electrochemical QCM: Applications to Studies of Thin Polymer Films, Electron Transfer Systems, Biological Macromolecules, Biosensors, and Cells;375 5.2.1;1 Introduction to Piezoelectric Techniques and the Quartz Crystal Microbalance;376 5.2.2;2 Studying Thin Film Systems with the QCM;380 5.2.3;3 Electron Transfer Studies of Chemical and Polymer Systems with the EQCM;390 5.2.4;4 EQCM Use in Studying Biochemical Processes, Biomimetic Systems and in Creating Biosensors;402 5.2.5;5 Applications of QCM to Studies of Cell Behavior;413 5.2.6;6 Future Prospects;420 5.2.7;References;423 5.3;The QCM-D Technique for Probing Biomacromolecular Recognition Reactions;429 5.3.1;1 A B