Dr. Melvin A. Shiffman, MD, JD, FCLM, received his MD from Northwestern University School of Medicine in 1957 and completed his residency in general surgery in 1964 at the Veterans Administration Hospital, Long Beach, California. Since then he has been continuously involved in oncologic surgery, reconstruction, and cosmetic surgery. In 2002, Dr. Shiffman became Chair of the Section of Surgery at Tustin Hospital and Medical Center and in 2009-10 he served as President of the American College of Legal Medicine. He is Editor Emeritus of the American Journal of Cosmetic Surgery, a member of the Scientific Committee of the American Journal of Aesthetic Medicine, and an examiner for the International Board of Cosmetic Surgery. He is also a former Editor-in-Chief of both the American Journal of Cosmetic Surgery and the International Journal of Cosmetic Surgery. Dr. Shiffman is the recipient of many honors and is a fellow of various colleges and societies. He has published 300 articles, authored or edited 34 books, and written more than 140 book chapters.

Dr. Mervin Low, MD received his MD from the University of British Columbia, Vancouver, BC, Canada. He completed his Plastic Surgery Residency at the University of Manitoba, Winnipeg, MB, Canada, and a Breast and Aesthetic Surgery fellowship at Georgetown University in Washington, DC, USA, and at the Plastic Surgery Center of the Pacific, Honolulu, HI, USA. Dr. Low has a busy practice devoted entirely to Aesthetic and Reconstructive Plastic Surgery.  He is a prolific author, educator and innovator.  He has been recognized locally as one of the Best Doctors in California and nationally as one of the Top Plastic Surgeons in America.

1;Foreword;5 2;Preface;7 3;Contents;8 4;Part I: Orthopedics;11 4.1;Management of Complex Distal Lower Extremity Wounds Using a Porcine Urinary Bladder Matrix (UBM-ECM);12 4.1.1;1 Introduction;12 4.1.2;2 Topical Wound Healing;28 4.1.3;3 Evolution of Orthopedic Management of Lower Extremity Injuries;29 4.1.4;4 Wound Bed Preparation;30 4.1.5;5 UBM-ECM Wound Treatment;30 4.1.6;6 Secondary Dressings;30 4.1.7;7 Clinical Series Report;31 4.1.8;8 Discussion;32 4.1.9;Conclusions;35 4.1.10;References;35 4.2;Uses of Negative-Pressure Wound Therapy in Orthopedic Trauma;39 4.2.1;1 Introduction;39 4.2.2;2 Components;39 4.2.3;3 Mechanism of Action;41 4.2.4;4 Application of the VAC Device;41 4.2.5;5 Clinical Indications;41 4.2.6;6 Complications and Recommendations;44 4.2.7;7 Authors' Preferred Treatment/Use;45 4.2.7.1;7.1 Cost;45 4.2.8;Conclusions;45 4.2.9;References;45 4.3;Prevention of Prosthetic Joint Infections;47 4.3.1;1 Prophylaxis;47 4.3.2;2 Preoperative Considerations;47 4.3.2.1;2.1 Medical Risk Factors;48 4.3.2.1.1;2.1.1 Diabetes;48 4.3.2.1.2;2.1.2 Obesity;48 4.3.2.1.3;2.1.3 Malnutrition;48 4.3.2.1.4;2.1.4 Tobacco Use;49 4.3.2.1.5;2.1.5 Alcohol Abuse;49 4.3.2.1.6;2.1.6 Immunosuppression;49 4.3.2.1.7;2.1.7 Oral Hygiene;50 4.3.2.1.8;2.1.8 Staphylococcus aureus Screening;50 4.3.2.1.9;2.1.9 Urine Screening;52 4.3.3;3 Perioperative Considerations;53 4.3.3.1;3.1 Patient Preparation;54 4.3.3.2;3.2 Skin Disinfection;54 4.3.3.3;3.3 Surgical Site Skin Preparation;54 4.3.3.4;3.4 Surgical Team Handwash;55 4.3.3.5;3.5 Prophylactic Antibiotics;55 4.3.3.5.1;3.5.1 Systemic Antibiotics;55 4.3.3.5.2;3.5.2 Antibiotic-Loaded Bone Cement;58 4.3.3.6;3.6 Operating Room Conditions;58 4.3.3.7;3.7 Surgical Team Equipment;59 4.3.3.8;3.8 Laminar Air Flow and Ultraviolet Lighting;59 4.3.3.9;3.9 Patient Homeostasis;60 4.3.3.10;3.10 Duration of Surgery;60 4.3.4;4 Postoperative Considerations;60 4.3.4.1;4.1 Drains and Blood Management;60 4.3.4.2;4.2 Wound Care;61 4.3.4.3;4.3 Urinary Catheter;62 4.3.4.4;4.4 Duration of Hospital Stay;62 4.3.5;5 Prevention of Late Haematogenous Infections;62 4.3.6;References;63 4.4;Greater Wound and Renal Complications in Gout Patients Undergoing Total Joint Arthroplasty;72 4.4.1;1 Introduction;72 4.4.2;2 Gout Definition and Risk Factors;72 4.4.3;3 Gout Epidemiology;73 4.4.4;4 Gout Comorbidities;73 4.4.5;5 Total Joint Arthroplasty Complications;74 4.4.6;6 Gout and Total Joint Arthroplasty Complications;74 4.4.7;7 Wound Complications in Gout TJA Patients;74 4.4.8;8 Renal Complications in Gout TJA Patients;76 4.4.9;Conclusions;76 4.4.10;References;76 4.5;Augmentation of Bone Healing in Delayed Union and Atrophic Nonunion of Fractures of Long Bones by Partially Decalcified Bone Allograft;78 4.5.1;1 Introduction;78 4.5.2;2 Bone Grafting;78 4.5.3;3 Biology of Incorporation of Bone Grafts;79 4.5.4;4 Preparation of Partially Decalcified Bone Allograft;79 4.5.5;5 Authors' Results;80 4.5.6;References;84 5;Part II: Ophthalmology;85 5.1;Corneal Wound Healing and Laser Refractive Surgery;86 5.1.1;1 Introduction;86 5.1.2;2 Corneal Wound Healing: An "Epithelium-Stroma" Interaction;86 5.1.3;3 Several Clinical Factors Have Been Correlated with Haze Formation;89 5.1.3.1;3.1 Degree of Myopia;89 5.1.3.2;3.2 Stromal Surfaces Irregularities After Treatment;89 5.1.3.3;3.3 Type of Laser;89 5.1.3.4;3.4 Ablation Procedure;89 5.1.3.5;3.5 Debridement Technique;90 5.1.3.6;3.6 UV Radiation Exposure;90 5.1.4;4 Pharmacological Modulation of Corneal Wound Healing;90 5.1.5;References;91 5.2;Corneal Epithelial Wound Healing and Management Strategies;95 5.2.1;1 Introduction;95 5.2.2;2 Corneal Structure;95 5.2.2.1;2.1 Tear Film;96 5.2.2.2;2.2 Corneal Epithelium;96 5.2.2.3;2.3 Stroma;97 5.2.2.4;2.4 Dua's Layer;97 5.2.2.5;2.5 Endothelium and Descemet's Membrane;97 5.2.2.6;2.6 The Limbus;98 5.2.3;3 Corneal Epithelial Wound Healing;98 5.2.3.1;3.1 Latency;98 5.2.3.2;3.2 Migration;98 5.2.3.3;3.3 Proliferation;99 5.2.3.4;3.4 Attachment;99 5.2.4;4 Regulation of Corneal Epitheli