The International Symposium on Positron Emission Tomography of the Brain was held at Schloss Auel in Lohmar, near Cologne, FRG, on May 3rd to 8th, 1982. This isolated place was chosen to bring together and keep together people active in research employing PET. The partic ipants were asked to report their ongoing work, to discuss upcoming problems, and to indicate future developments. In contrast to the large international meetings which suffer from lack of time for discussion and are affected by the distractions of major cities, our symposium provided ample opportunity for discussion during the scientific sessions and guaranteed a free exchange of ideas during the leisure time spent to gether. It also gave us the chance to celebrate the founding of a new Max Planck Institute for Neurological Research, whose two depart ments are headed by Dr. K. -A. Hossmann and myself, and to mark the start of positron emission tomography in our laboratory. The book contains the invited papers presented at the meeting and the formal minipapers given at the final general discussion, moderated su perbly by Dr. L. Sokoloff. In order to accelerate publication, the discus sions of the individual papers and the final discussion have been omit ted. However, every participant will remember the atmosphere and the highlights of the discussions, which gave a special character to the whole event.

Principles

Biochemical Principles for the Measurement of Metabolic Rates in Vivo
Experimental Application of Triple-Labeled Quantitative Autoradiography for Measurement of Cerebral Blood Flow, Glucose Metabolism and Protein Biosynthesis
Methodology
New Design Concepts for Quantitive Positron Emission Computed Tomography of the Brain
Design Characteristics of a Multiring Positron Camera System for Emission Tomography of the Brain
Design Concepts and Performances of HEADTOME, a Multiring Hybrid Emission Tomograph for the Brain
Radiochemicals
Labeled Compounds for Positron Emission Tomography
Biochemical Parameters in Radiopharmaceutical Design
Cerebral Blood Flow
Regional Cerebral Blood Flow Measurement and Dynamic Positron Emission Tomography
The Measurement of Regional Cerebral Blood Flow in Man Using an in Vivo Autoradiographic Technique and Positron Emission Tomography
Regional Cerebral Blood Flow Measurement with Fluoromethane and Positron Tomography
A Method for Local Evaluation of the Volume of Rapidly Exchangeable Water in the Human Brain
Oxygen Consumption
Measurement of Regional Cerebral Oxygen Consumption and Blood Flow in Man
Clinical Application of Measurement of Regional Cerebral Blood Flow and Oxygen Utilization by Positron Emission Tomography
Positron Emission Tomography of Stroke Patients
Local Cerebral Blood Flow and Oxygen Consumption in Evolving Irreversible Ischemic Infarction
Glucose Metabolism
Mapping Local Cerebral Glucose Utilization in Normal Aging and in Cerebrovascular, Degenerative, and Epileptic Disorders
Human Sensory Stimulation and Deprivation as Demonstrated by Positron Computed Tomography
Measurement of Local Cerebral Glucose Metabolism: Application to the Study of Stroke
Remote FunctionalDepression of Glucose Metabolism in Stroke and its Alteration by Activating Drugs
Regional Perfusion and Glucose Uptake Determination with 11C-Methyl-Glucose and Dynamic Positron Emission Tomography
Glycolytic Rate and Histologic Grade of Human Cerebral Gliomas: A Study with [18F] Fluorodeoxyglucose and Positron Emission Tomography
Positron Emission Tomography Studies of Brain Energy Metabolism in Schizophrenia
Regional Correlations in Patterns of Glucose Use in Patients with Schizophrenia and Normal Subjects During Mild Pain Stimulation
Evaluation of Regional Glucose Metabolism with Positron Emission Tomography in Normal and Psychiatric Populations
Protein Synthesis and Receptor Studies
Local Brain Protein Metabolism in Dementia and Schizophrenia: In Vivo Studies with 11C-L-Methionine and Positron Emission Tomography
Brain Regional Pharmacokinetics of 11C-Labeled Diphenylhydantoin and Pimozide in Man
Mini-Papers
Potential Bromine-75-Labeled Brain Radiopharmaceuticals
Biochemical Prerequisites for Measurement of Protein Synthesis
Discrepancy Between Glucose Availability and Calculated Glucose Consumption During Acute Brain Ischemia
The Relationship of Regional Cerebral Blood Flow, Oxygen Metabolism and Glucose Metabolism Following Acute Stroke.