1;Preface;5 2;Contents;6 3;Introduction: History and Progress of Objective Skin Analysis;8 4;Part I:Legal Aspects of Cosmetic Testing;11 4.1;1: Regulatory Aspects;12 4.1.1;1.1Comparison Between General Cosmetic Legislation in Europe and Other Countries;13 4.1.2;1.2Recent Changes in European Cosmetic Regulation;14 4.1.3;1.3Important Weblinks;15 4.1.3.1;1.3.1European Union;15 4.1.3.2;1.3.2USA;15 4.1.3.3;1.3.3Canada;16 4.1.3.4;1.3.4Japan;16 4.1.3.5;1.3.5Mercosur Countries (Examples);16 4.1.3.6;1.3.6ASEAN Countries (Example);16 4.1.3.7;1.3.7South Africa;17 4.1.3.8;1.3.8China;17 4.1.3.9;1.3.9India;17 4.1.4;1.4Cosmetic Safety Testing;17 4.1.5;1.5Responsibility Considerations for Planning and Conduct of a Cosmetic Safety Study;18 4.1.6;1.6Frequent Cosmetic Safety Study Models;19 4.1.7;1.7Cosmetic Efficacy Testing;20 4.1.8;1.8Cosmetic Labeling and Packaging;21 4.1.9;References;22 4.2;2: Ethical Aspects of Cosmetic Testing;23 4.2.1;2.1Introduction;23 4.2.2;2.2Brief History of Research Ethics;24 4.2.3;2.3Ethical Aspects of Cosmetic Testing;27 4.2.4;2.4Ethical Aspects of Noninvasive Skin Measurements;27 4.2.5;2.5Essential Ethical Requirements for Performing a Study;28 4.2.5.1;2.5.1Principles Related to Study Conduct;28 4.2.5.2;2.5.2Principles Related to Study Investigator;28 4.2.5.3;2.5.3Principles Related to Study Subjects/Participants;29 4.2.5.4;2.5.4Principles Related to Investigational Products;29 4.2.5.5;2.5.5Principles Related to Measuring Techniques/Devices;30 4.2.5.6;2.5.6Principles Related to Institutional Review Board/Independent Ethics Committee (IRB/IEC);30 4.2.5.7;2.5.7Other Considerations;30 4.2.6;2.6Conclusion;31 4.2.7;2.7Key Messages for Performing an Ethical Study;31 4.2.8;References;31 4.3;3: Good Clinical Practice;34 4.3.1;3.1Principles of GCP;34 4.3.2;3.2Standard Operating Procedures (SOPs);36 4.3.3;3.3Study Design and Protocol Standards;37 4.3.4;3.4Conduct Standards;37 4.3.5;3.5Recording and Reporting Standards;37 4.3.6;References;38 4.4;4: Guidelines in Dermocosmetic Testing;39 4.4.1;4.1Introduction;39 4.4.2;4.2Skin Bioengineering Endeavor;40 4.4.3;4.3Validation of Methods and Instrumentations;41 4.4.4;4.4A Plea for Standardization and Quality Controls;41 4.4.5;4.5Search for "Good Biometrological Practice";42 4.4.6;4.6Guidelines in Perspective;44 4.4.7;4.7Conclusion;45 4.4.8;References;46 4.5;5: Claim Support: How to Create and Substantiate Claims;48 4.5.1;5.1Introduction: Cosmetic Claims and Cosmetic Product Testing;48 4.5.1.1;5.1.1What Is a Cosmetic Claim?;49 4.5.1.2;5.1.2Borderline Claims;50 4.5.2;5.2The Process of Creating Cosmetic Claims;50 4.5.2.1;5.2.1Global or Regional;52 4.5.2.2;5.2.2Communication Style and Medium;52 4.5.2.3;5.2.3Consumer Factors;53 4.5.3;5.3Deciding How to Support a Claim;53 4.5.3.1;5.3.1 Classifying Claims;54 4.5.3.2;5.3.2Level of Evidence;55 4.5.3.2.1;5.3.2.1Established and Widely Available Evidence;55 4.5.3.2.2;5.3.2.2Established Rationale but Requiring Specific Evidence;57 4.5.3.2.3;5.3.2.3Evidence Based upon Significant Advance in Science or Technology;58 4.5.4;5.4Generating Information to Support Claims;58 4.5.5;5.5Presenting Information in Support of a Claim;63 4.5.6;5.6State of the Art;64 4.5.7;5.7Conclusion;65 4.5.8;References;65 5;Part II:General Aspects of Cosmetic Testing;67 5.1;6: Testing Laboratory;68 5.1.1;6.1Requirements for Accommodation and Arrangement;69 5.1.1.1;6.1.1Reception/Volunteer Recruitment Office;70 5.1.1.2;6.1.2Data Base/Subject File Room;70 5.1.1.3;6.1.3Waiting Area for Volunteers;70 5.1.1.4;6.1.4Room for Conducting General Volunteer Information Sessions;71 5.1.1.5;6.1.5Investigator's Office(s)/Examination Room(s);71 5.1.1.6;6.1.6Testing Lab Room(s);71 5.1.1.7;6.1.7Staff Office(s);72 5.1.1.8;6.1.8Rest Rooms for Volunteers;72 5.1.1.9;6.1.9Test Product/Sample Storage Room;72 5.1.2;6.2Requirements for Ambient Conditions;73 5.1.3;6.3Laboratory Quality Management System;73 5.1.3.1;6.3.1General Quality Management;73 5.1.3.2;6.3.2Measurement Devices Quality Managemen