Preparative Polar Organometallic Chemistry is a collection of laboratory procedures for the synthesis and functionalization of organoalkali and Grignard compounds. The second volume with methods for generation and transformation of compounds bearing the metal at an sp3 carbon complements the first in which the metal was bound to an sp2 carbon atom in the reagent. Synthetically important intermediates such as metallated S,S-acetales, imines, nitriles, isonitriles and ketones are illustrated. All procedures have been worked out in full detail and tested in the author's own laboratory. Both books are intended to be practical bench-top laboratory manuals for working organic chemists, from the student to the advanced scientist.

I. Reactivity of Polar Organometallic Intermediates

1 Introduction
2 Alkylation
3 Hydroxyalkylation with Epoxides
4 Hydroxyalkylation with Carbonyl Compounds
5 Formylation with Dimethylformamide
6 Carboxylation
7 Reaction of Organoalkali Compounds with Carbon Disulfide
8 Addition of Organoalkali Compounds to Isocyanates and Isothiocyanates
9 Sulfenylation
10 Trimethylsilylation
11 Reactions of Organometallic Compounds with Chloroformates and Dimethylcarbamoyl Chloride
12 Reactions of Organoalkali Compounds with Halogenating Agents
13 Conjugate Additions
II. Metallation of Aromatic and Olefinic Hydrocarbons
1 Introduction
2 Metallation of Alkylbenzenes and Alkylnaphthalenes
3 Dimetallation of Aromatic Compounds
4 Metallation of Olefinic Compounds
5 Stereochemistry of Allylic Metallations
6 Dimetallation of Olefins
7 Experiments
8 Selected Procedures from Literature
III. Metallation of Saturated Sulfur Compounds
1 Introduction
2 Substrates and Metallation Conditions
3 Experiments
4 Selected Procedures from Literature
IV. ?-Metallation of Derivatives of Toluene Containing Heterosubstituents
1 Scope of this Chapter
2 Experiments
V. Metallation of Heterosubstituted Allylic and Benzylic Compounds
1 Introduction
2 Substrates and Metallation Conditions
3 Experiments
VI. Metallation of Heterocyclic Compounds
1 Introduction
2 Metallation of Alkyl Derivatives of Pyridine and Quinoline
3 Lateral Metallation of 2-Substituted Oxazolines, Thiazolines, Dihydrooxazines and Thiazoles
4 Experiments
5 Organic Syntheses Procedures
VII. Metallation of Aldimines and Ketimines
1 Introduction
2 Conditions for the Metallation
3 Experiments
4 Organic Syntheses Procedures
VIII. Metallation of Nitriles andIsonitriles
1 Introduction
2 ?-Metallation of Nitriles
3 Metallation of Isonitriles
4 Experiments
IX. Generation of Lithium Halocarbenoids
1 Introduction
2 Methods of Generation of Lithium Halocarbenoids
3 Experimental Conditions and Techniques in Carbenoid Chemistry
4 Experiments
X. Metallation of Carbonyl and Thiocarbonyl Compounds
1 Introduction
2 Mono Metallation of Carbonyl and Thiocarbonyl Compounds
3 Other Methods for the Generation of Enolates and Enethiolates
4 Dimetallation of Carbonyl and Thiocarbonyl Compounds
5 Experiments
Metallation-Functionalization Index (Vol. 2)
Syntheses of Reagents and Starting Compounds (Vols. 1 and 2).
Complementary Index (Vols. 1 and 2)
Typical Procedures and Special Techniques (Vols. 1 and 2)
Purification and Storage and Some Reagents and Solvents (Vols. 1 and 2).