1;Preface by the Series Editor;6 2;Foreword;7 3;Contents;8 4;1 Introduction;11 5;2 Medical imaging methods;14 5.1;2.1 Signal penetration;15 5.2;2.2 Tissue interaction;17 5.3;2.3 Signal confinement/resolution;18 5.4;2.4 Overview of existing imaging methods;20 5.5;2.5 Conclusions for successful new imaging modalities;24 6;3 Basic idea of Magnetic Particle Imaging;27 6.1;3.1 Signal generation and recording;27 6.1.1;3.1.1 Signal generation ;27 6.1.2;3.1.2 Signal confinement;31 6.1.3;3.1.3 Drive field;33 6.2;3.2 Reconstruction;35 7;4 Magnetic particle properties;40 7.1;4.1 Demagnetization factor ;40 7.2;4.2 Single domain particles and the Langevin theory;43 7.3;4.3 Remagnetization processes;45 7.4;4.4 Magnetic anisotropy;47 7.5;4.5 Particle-particle interactions;50 8;5 The Focus Field;52 8.1;5.1 Patient safety;52 8.2;5.2 Technical limitations;53 8.3;5.3 Additional fields, the focus fields;53 9;6 Resolution, sensitivity and speed;55 9.1;6.1 Unlimited resolution?;55 9.2;6.2 Sensitivity;57 9.2.1;6.2.1 Signal strength;58 9.2.2;6.2.2 Patient noise;58 9.2.3;6.2.3 Detection limit of MPI;59 9.2.4;6.2.4 Detection limit of MRI;60 9.2.5;6.2.5 Detection limit of CT;60 9.2.6;6.2.6 Detection limit of PET and SPECT;62 9.3;6.3 Encoding efficiency;63 9.4;6.4 Speed limit;71 9.4.1;6.4.1 MPI encoding speed;71 9.4.2;6.4.2 Ultrasound encoding speed;72 9.4.3;6.4.3 CT encoding speed;72 9.4.4;6.4.4 MRI encoding speed;73 10;7 Experimental and simulation results on MPI;75 11;8 Potential applications of MPI;79 11.1;8.1 Combination with magnetic resonance imaging;79 11.2;8.2 Vascular applications;82 11.2.1;8.2.1 Cardiovascular;83 11.2.2;8.2.2 Neurovascular;85 11.3;8.3 Gastrointestinal;86 11.4;8.4 Lung;87 11.5;8.5 RES imaging/direct inflammation imaging;87 11.6;8.6 Cell labelling;88 11.6.1;8.6.1 Red blood cell labelling;88 11.6.2;8.6.2 White blood cell labelling;89 11.6.3;8.6.3 Stem cell labelling;90 11.7;8.7 Sentinel lymph node imaging;90 11.8;8.8 Hyperthermia;91 12;9 Potential further developments and applications;93 12.1;9.1 Tissue intrinsic contrast MPI;93 12.2;9.2 Targeted imaging;93 12.3;9.3 Lung diffusion imaging;94 12.4;9.4 Temperature imaging;95 12.5;9.5 MPI-acoustic imaging and Elastography;97 12.6;9.6 Pulmonary artery pressure;98 12.7;9.7 Object tracking and manipulation;100 12.8;9.8 Electrophysiology imaging;102 12.9;9.9 Light modulation;104 12.10;9.10 X-ray modulation;105 12.11;9.11 Targeted drug delivery;105 13;10 Conclusion;107 14;Bibliography;112