Present knowledge in regional cancer therapy is presented in this volume. The latest research addresses the questions of optimal drug development, the best galenic form and schedule to control tissue distribution at the tumor site and efficient treatment of specific anatomical regions.

Advances in Drug Delivery

Advances in Drug Delivery to Cancer Patients: Introduction
Technical Developments in the Delivery of Antineoplastic Agents
Is There a Pharmacologic Rationale for Continuous Cancer Chemotherapy?
Central Venous Access in Children Through a Fully Implantable Drug Delivery System
Intraportal Chemotherapy for Colorectal Hepatic Metastases
Liver Metastases
Prophylactic and Adjuvant Regional Chemotherapy of the Liver in Colorectal Malignancies
Randomized Multicenter Trial on Adjuvant Intraportal Chemotherapy for Colorectal Cancer (SAKK 40/81)
Enhancement of Cytotoxic Efficacy of 5-Deoxy-5-fluorouridine in Acetoxymethyl-methylnitrosamine-Induced Colorectal Adenocarcinomas in SD Rats by Locoregional Administration into the Inferior Mesenteric Artery
Second Hepatic Resections in Patients with Liver Metastases from Colorectal Carcinoma
Six Years of Experience with Local Chemotherapy of the Liver
Regional Therapy of Hepatic Metastases: Prognostic Factors
Regional Therapy with 5-Fluorouracil: Dependence of Systemic Concentrations on the Infusion Rate
Combined Regional and Systemic Chemotherapy in Hepatic Metastases of Colorectal Carcinoma: Continuous IA Vs Simultaneous IA/IV FUDR Infusion
Intra-arterial Chemotherapy of Liver Metastases
Current Standards and Limits in Treatment of Hepatic Metastases
Degradable Starch Microspheres in Intra-arterial Tumor Treatment: An Overview
Increasing the Uptake of a Low Molecular Weight Marker in Liver Tumours by Degradable Starch Microspheres: Possible Mechanisms of Action
Dextrane Particle Use in Regional Chemotherapy: Problems of Monitoring
Chemoembolization of Hepatic Tumors with Degradable Starch Microspheres
Head and Neck Tumors
Cytostatic Treatment of Advanced Squamous Cell Carcinoma of the Maxillofacial Region
A Complex Chemotherapeutic Concept in the Treatment of Oral Carcinomas with Cisplatin and 5-Fluorouracil
Pathological Assessment of the Results of Intra-arterial Chemotherapy for Head and Neck Carcinomas by Serial Sections of the Whole Specimen
The Bypass Method in Head and Neck Cancer
Intratumoral Treatment of Incurable Head and Neck Cancer with Recombinant Human Tumor Necrosis Factor-?
Preoperative Local Immunotherapy with OK-432 (Picibanil) in Patients with Squamous Cell Cancer of the Oral Cavity
Extremity Tumors
Intra-arterial Chemotherapy, Preoperative and Postoperative Radiotherapy, and Surgery for Primary "Unresectable" High-Grade Soft Tissue Sarcomas of the Extremities
Regional Induction Chemotherapy Followed by Radiotherapy and/or Surgery in Management of Large and Aggressive Sarcomas in Shoulder, Pelvis and Limbs
Neo-adjuvant Chemotherapy for Osteosarcoma of the Extremities: The Experience at the Rizzoli Institute in 210 Patients Treated with Two Successively Activated Preoperative Protocols Using High-Dose or Moderate-Dose Methotrexate + Cisplatin or High-Dose Methotrexate + Cisplatin + Doxorubicin
Neo-adjuvant Therapy of Soft Tissue Sarcomas of the Extremities with Intra-arterial Chemotherapy and Radiation
Melanoma
Isolation Perfusion for Malignant Melanomas: Established Facts and Parameters to Be Clarified
Regional Extremity Perfusion in Patients with Malignant Melanoma
Preliminary Results of a Double Perfusion Schedule with Melphalan in Measurable Melanoma
Melphalan in Isolated Limb Perfusion for Malignant Melanoma, Bolus for Divided Dose, Tissue Levels, the pH Effect
Isolation Perfusion of Malignant Soft Tissue Tumors
Intravesical Therapy
The Effect of Topical Adriamycin in Superficial Bladder Tumors: A 5-Year Follow-up
Topical Instillation of Mitomycin C in the Treatment of Superficial Bladder Tumors: Long-Term Observation
Mitomycin and Hyaluronidase in the Prevention of Recurrent Bladder Tumor
How Effective is Topical Interferon-?2b for Preventing Recurrence of Superficial Bladder Cancer
Neo-adjuvant Intra-arterial Chemotherapy for Treatment of Locally Advanced Bladder Cancer: Therapeutic Protocol and Preliminary Report
Radiotherapy
Reconstructive Microsurgery and Radiotherapy in Advanced Tumors of the Head and Neck
Palliation of Nonresectable Esophageal Cancer by Irridium-192 Intraluminal Afterloading
Interstitial Radiotherapy with Iridium-192 in the Treatment of Early Breast Cancer
Intracavitary High-Dose-Rate Afterloading Irradiation in the Treatment of Cancer of the Esophagus and Gastroesophageal Junction
External Radiotherapy for Local and Regional Control of Lung Cancer
Hyperthermia
Clinical Experience with a Multifrequency Hyperthermia System and Chemotherapy in the Treatment of Superficial Metastases
Recent Clinical Experience with an Annular Phased Array Hyperthermia System in the Treatment of Advanced Recurrences in the Pelvis
The Viennese Interstitial System KHS 9/W 18: Homogenous Hyperthermia with Simultaneous Radiation in Deep-seated Tumors with Integrated Heat Protection of Normal Tissue
Thermoradiotherapy of Superficial and Half-Deep-seated Tumors: Thermal Profiles and Tumor Response
Comparison of Leakage Measurement Using 99mTc-Labeled Red Blood Cells and Peripheral Melphalan Determination in Hyperthermic Isolation Perfusion of the Extremities
Clinical and Histopathological Aspects of Hyperthermic Isolated Regional Perfusion of Soft Tissue Sarcomas of the Extremities
Laser Therapy
Experimental Basis of CO2 Laser Application in Tumor Surgery
Experience with CO2 Laser in Tumor Surgery
Nd: YAG Laser Application in the Surgical Treatment of Cancer
Neodymium: YAG Laser Therapy in Gastroduodenal Cancer
Innovative Approaches
The Use of Tumor-Infiltrating Lymphocytes in Cancer Therapy
Adoptive Immunotherapy for Renal Adenocarcinoma: Use of Oxidizing Mitogen-Treated Mononuclear Leukocytes and Continuous Infusion of Interleukin-2
Processing of Antigen-Antibody Complexes at the Level of the Tumor Cell
Regional Immunotherapy and Chemotherapy in Lung Cancer.