This book provides an up-to-date and comprehensive overview of protein phosphatase research, a rapidly evolving field with increasing importance in our understanding of the molecular basis of cell biology and of pathological processes.

The book covers dephosphorylation processes involving serine/threonine, as well as tyrosine and histidine residues, and aims to be a useful resource for both the advanced reader as well as the newcomer to the field. It is also valuable for those working in the pharmaceutical and Biotech industries.

Overview of Protein Serine/Threonine Phosphatases

Protein Phosphatase 1
Protein Phosphatase 2A: A Multifunctional Regulator of Cell Signaling
Calcineurin: Roles of the Ca2+/Calmodulin-dependent Protein Phosphatase in Diverse Eukaryotes
Roles of Mammalian Protein Phosphatase 2C Family Members in the Regulation of Cellular Functions
PP5: the TPR Phosphatase
Protein Histidine Phosphatases in Signal Transduction and Metabolism
Anchoring of Protein Kinase and Phosphatase Signaling Units
Functional Proteomics in Phosphatase Research
Structure and Function of the T-cell Protein Tyrosine Phosphatase
Protein Tyrosine Phosphatase-based Therapeutics: Lessons From PTP1B
The CD45 Phosphotyrosine Phosphatase
Receptor Protein Tyrosine Phosphatases
The Shp-2 Tyrosine Phosphatase
SHP-1 Twelve Years on: Structure, Ligands, Substrates and Biological Roles
The Dual-specific Protein Tyrosine Phosphatase Family
Tyrosine Phosphatases in Cancer: Targets for Therapeutic Intervention.