Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions.

This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Organization of Scaffolds

A-Kinase Anchoring Proteins as the Basis for cAMP Signaling
Arrestins as Multi-Functional Signaling Adaptors
Role of Ena/VASP Proteins in Homeostasis and Disease
Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy
Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox?
Scaffolding Proteins and Cellular Signalling
PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases
G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains
Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design
Compartmentalised MAPK Pathways
Dynamic Protein Complexes Regulate NF-?B Signaling
An Oncogenic Hub: ?-Catenin as a Molecular Target for Cancer Therapeutics
A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling
Cell Type-Specific Anchoring
Scaffolding Proteins in Cardiac Myocytes
Molecular Architecture of Signal Complexes Regulating Immune Cell Function
Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework
Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept
Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies
Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition
Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors
Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs
Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets.