This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. 

Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Part I. Cancer

Ubiquitin-Regulated Cell Proliferation and Cancer
Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer
The Proteasome System in Health and Disease
Proteostasis Dysregulation in Pancreatic Cancer
Divergent Modulation of Proteostasis in Prostate Cancer
Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma
Part II. Neurodegeneration
Altered Proteostasis in Neurodegenerative Tauopathies
The Ubiquitin System in Alzheimer's Disease
The Interplay Between Proteostasis Systems and Parkinson's Disease
Machado-Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides
Part III. Infection, In ammation and Developmental Disorders
SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends
The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication
By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System
TRIME3 Ubiquitin Ligases in Rare Genetic Disorders
Part IV. Diet
We Are What We Eat: Ubiquitin-Proteasome System (UPS) Modulation Through Dietary Products.