1.1 Outline of the Study In this study the influence of psychotropic drugs on anterior pituitary hormone (APR) secretion was investigated in healthy subjects and in depressed patients. The basis for this study is formed by pharmacological investigations which indicate that the therapeutic effect of psychotropic drugs can be attributed to their functional influence on central nervous aminergic impulse transmission (stimuli) as well as by endocrinological investigations which show that central nervous aminergic neurons influence APR secretion in man. The purpose was to frod out if psychotropic drugs with differing pharmacological actions also influence APR secretion differently, even though the complex processes of central nervous stimuli transmission, the effect of psychotropic drugs on these processes, as well as the action of aminergic neuronal systems on APR secretion are not completely understood. Furthermore, it was investigated if it is possible to reach conclusions on the effects of drugs on central nervous aminergic neurons based upon APR secretion data. Specifically, the effects of various antidepressants, neuroleptics, and benzodiazepine-type tranquilizers on the secretion of growth hormone (GR), prolactin (PRL), adrenocorticotropic hormone (ACTR), and cortisol were investigated in healthy male subjects. The first part of this study presents in detail the results of these experiments and also incorporates the results of other investigators. It is endeavored to answer the question whether and to what extent the different psychotropic drugs influence APR secretion and whether the APR secretion profiles of the different psychotropic drugs can serve as a possible pharmacoendocrinological model in humans.

1 Introduction

1.1 Outline of the Study
1.2 Effect of Psychotropic Drugs on Central Nervous Aminergic Stimuli Transmission
1.3 Influence of Aminergic Neuronal Systems on Anterior Pituitary Hormone Secretion
1.4 Aminergic Neurons, APH Secretion and Depression Research
2 Influence of Psychotropic Drugs on Anterior Pituitary Hormone Secretion in Healthy Subjects
2.1 Healthy Subjects and Methods
2.2 Influence of Psychotropic Drugs on GH Secretion
2.3 Influence of Psychotropic Drugs on Prolactin Secretion
2.4 Influence of Psychotropic Drugs on Cortisol/ACTH Secretion
2.5 Discussion
3 Influence of Receptor Blockers and Receptor Agonists on Antidepressant-Induced Anterior Pituitary Hormone Secretion in Healthy Subjects
3.1 Healthy Subjects and Methods
3.2 Influence of Receptor Blockers and Receptor Agonists on DMI-Induced GH Stimulation
3.3 Influence of Receptor Blockers and Receptor Agonists on DMI-Induced PRL Stimulation
3.4 Influence of Receptor Blockers and Receptor Agonists on DMI-Induced Cortisol/ACTH Stimulation
3.5 Discussion
4 Desipramine-Induced Growth Hormone Stimulation in Depressive Patients and Healthy Subjects
4.1 GH Secretion after Desipramine in Depressive Patients and Healthy Subjects
4.2 Healthy Subjects, Patients, and Methods
4.3 Results
4.4 Summary and Discussion
5 Summary
6 Reference.