Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations.

What Is a Quasispecies?

Quasispecies in Time-Dependent Environments
Viruses as Quasispecies: Biological Implications
Virus Fitness: Concept, Quantification, and Application to HIV Population Dynamics
Population Bottlenecks in Quasispecies Dynamics
Evolutionary Dynamics of HIV-1 and the Control of AIDS
Evolution of Virulence in Picornaviruses
Molecular Mechanisms of Poliovirus Variation and Evolution
Hepatitis C Virus Population Dynamics During Infection
Evolutionary Influences in Arboviral Disease
Arenavirus Diversity and Evolution: Quasispecies In Vivo
Mutant Clouds and Occupation of Sequence Space in Plant RNA Viruses
Parvovirus Variation for Disease: A Difference with RNA Viruses?
Transitions in Understanding of RNA Viruses: A Historical Perspective.