In this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that still must be overcome before this promising technology is finally ready for translation and clinical use.

MicroRNA

An Overview of MicroRNA
MicroRNAs and Their Potential
miRNAs and Their Emerging Role in Cardiac Hypertrophy
MicroRNAs and the Control of Heart Pathophysiology
MicroRNA Systems Biology
RNA Interference
Targeting Viral Heart Disease by RNA Interference
Design of siRNAs and shRNAs for RNA Interference: Possible Clinical Applications
RNA Interference and MicroRNA Modulation for the Treatment of Cardiac Disorders
Cardiac Delivery of Nucleic Acids by Transcriptional and Transductional Targeting of Adeno-Associated Viral Vectors
Ribozymes
Characterization of Hammerhead Ribozymes Potentially Suitable for the Treatment of Hyper-Proliferative Vascular Diseases
Applications of Ribozymes and Pyrrole-Imidazole Polyamides for Cardiovascular and Renal Diseases
Noncoding, Aptamer and Antisense RNAs
Noncoding RNAs in Human Diseases
Aptamers and siRNAs in Cardiovascular Disease
Nucleic Acid Aptamers for Cardiovascular Therapeutics
NF?B Decoy Oligodeoxynucleotide-Based Therapy in Cardiovascular Diseases
Antisense Therapy for Restenosis Following Percutaneous Coronary Interventions
Toxic RNA in Pathogenesis of Human Neuromuscular Disorders.