Das Buch untersucht die genetische Epidemiologie von seltenen und häufigen Tumoren. Neben Hinweisen zu statistischen und methodischen Ansätzen werden Computermodelle zur Datenspeicherung und Analyse vorgestellt. Der starke klinische Bezug zusammen mit dem neuen Ansatz zur Krebsetiologie liefert neue Anregungen zur zukünftigen Forschung.

I. Introduction

Genetics of Common Tumors
Pitfalls and Prospects in Genetic Epidemiology of Cancer
II. Studies on Genetic Epidemiology
Familial Susceptibility to Breast Cancer
Linkage Mapping of Cancer Susceptibility Genes
Genetic Epidemiology of Retinoblastoma
Genetic Epidemiology of Cancer and Predisposing Lesions
Search for Genetic Factors in the Etiology of Breast Cancer
Molecular, Cytogenetic and Linkage Analysis of Chromosome 11p Regions Involved in Wilms' Tumour and Associated Congenital Diseases
Analysis of Association in Nuclear Families
Ascertainment Problems in Family Data: Methodological Aspects
Polygenic vs Monogenic Inheritance of Dysplastic Nevi and Malignant Melanoma: Yesterday's Debate or the Answer of Tomorrow?
Genetic Epidemiology and the Familial Atypical Multiple Mole Melanoma Syndrome
III. Computer Applications
Computer Simulation Methods in Human Linkage Analysis
Computer Programs for Linkage Analysis
A Comprehensive Pedigree Analysis Tool: FAP (Family Analysis Package)
List of Abbreviations
Subjeet Index.