Asymmetric Organocatalysis comprehensively covers all the catalysts and reactions within the activation modes Lewis base catalysis and Lewis acid catalysis. Typical or general experimental procedures as well as mechanistic, technical and theoretical aspects are included, allowing the reader to clearly see how simple, clean and efficient this chemistry is.

• Authoritative, broad overview of the field, compiled by 36 experts
• Critical presentation of the best organocatalytic and related methodologies available today for practical asymmetric synthesis
• Provides alternative, greener syntheses with simple and easily used catalysts helping avoid the use of expensive and/or toxic metals

1;Science of Synthesis: Asymmetric Organocatalysis 1 - Lewis Base and Acid Catalysts;1 1.1;Organizational Structure of Science of Synthesis;2 1.2;Science of Synthesis Reference Library;3 1.3;Title page;5 1.4;Imprint;7 1.5;Preface;8 1.6;Asymmetric Organocatalysis Volumes;10 1.7;Abstracts;12 1.8;Overview;24 1.9;Table of Contents;26 1.10;1.1 Lewis Bases;42 1.10.1;1.1.1 Enamine Catalysis of Intramolecular Aldol Reactions;42 1.10.1.1;1.1.1.1 Enamine Catalysis of Intramolecular Enolendo Aldol Reactions;43 1.10.1.1.1;1.1.1.1.1 Starting from Triketones;43 1.10.1.1.2;1.1.1.1.2 Starting from Diketones;61 1.10.1.2;1.1.1.2 Enamine Catalysis of Intramolecular Enolexo Aldol Reactions;64 1.10.1.2.1;1.1.1.2.1 Starting from Dialdehydes;64 1.10.1.2.2;1.1.1.2.2 Starting from Keto Aldehydes;66 1.10.1.3;1.1.1.3 Enamine Catalysis of Intramolecular Transannular Aldol Reactions;68 1.10.1.3.1;1.1.1.3.1 Starting from Diketones;68 1.10.2;1.1.2 Enamine Catalysis of Intermolecular Aldol Reactions;76 1.10.2.1;1.1.2.1 Structural Requirements for Enamine Catalysts of the Aldol Reaction;80 1.10.2.2;1.1.2.2 Reactions Using Ketone Donors;81 1.10.2.2.1;1.1.2.2.1 Reactions Catalyzed by Proline;82 1.10.2.2.2;1.1.2.2.2 Reactions Catalyzed by Proline Derivatives;85 1.10.2.2.3;1.1.2.2.3 Reactions Catalyzed by Other Amino Acid Derivatives;89 1.10.2.2.4;1.1.2.2.4 Reactions Catalyzed by Other Chiral Amines;92 1.10.2.3;1.1.2.3 Reactions Using Aldehyde Donors;96 1.10.2.3.1;1.1.2.3.1 Reactions Catalyzed by Proline;96 1.10.2.3.2;1.1.2.3.2 Reactions Catalyzed by Proline Derivatives;100 1.10.2.3.3;1.1.2.3.3 Reactions Catalyzed by Other Chiral Amines;105 1.10.3;1.1.3 Enamine Catalysis of Mannich Reactions;114 1.10.3.1;1.1.3.1 Mannich Reaction of N-Arylimines with Carbonyl Compounds;116 1.10.3.1.1;1.1.3.1.1 Three-Component Mannich Reaction;117 1.10.3.1.1.1;1.1.3.1.1.1 Reaction of Ketones;117 1.10.3.1.1.2;1.1.3.1.1.2 Reaction of Aldehydes;134 1.10.3.1.2;1.1.3.1.2 Two-Component Mannich Reaction;138 1.10.3.1.2.1;1.1.3.1.2.1 Reaction of Ketones;138 1.10.3.1.2.2;1.1.3.1.2.2 Reaction of Aldehydes;144 1.10.3.1.3;1.1.3.1.3 anti-Selective Reaction of N-Arylimines;148 1.10.3.2;1.1.3.2 Mannich Reaction of N-Carbamoyl- and N-Sulfonylimines with Carbonyl Compounds;156 1.10.3.3;1.1.3.3 Mannich Reaction of Other Imines: N-Alkylimines, Cyclic Imines, and Ketimines;167 1.10.4;1.1.4 Enamine Catalysis of Michael Reactions;176 1.10.4.1;1.1.4.1 Intramolecular Michael Reactions;177 1.10.4.1.1;1.1.4.1.1 Intramolecular Michael Reaction of Aldehydes with Enones;177 1.10.4.1.2;1.1.4.1.2 Synthesis of Bicyclic and Tetracyclic Compounds via Intramolecular Michael Reaction of Aldehydes with Enones;179 1.10.4.1.3;1.1.4.1.3 Intramolecular Michael Reaction of Aldehydes with Enals;182 1.10.4.1.4;1.1.4.1.4 Intramolecular Michael/Isomerization Reaction of Enals with Enones;183 1.10.4.1.5;1.1.4.1.5 Intramolecular Reductive Michael Reaction of Enals with Enones;184 1.10.4.1.6;1.1.4.1.6 Intramolecular Michael Reaction of Aldehydes with Vinyl Sulfones;186 1.10.4.2;1.1.4.2 Intermolecular Michael Reactions;186 1.10.4.2.1;1.1.4.2.1 Intermolecular Michael Reaction with a,ß-Unsaturated Carbonyl Compounds as Acceptor;187 1.10.4.2.1.1;1.1.4.2.1.1 Intermolecular Michael Reaction of Ketones with Enones;188 1.10.4.2.1.2;1.1.4.2.1.2 Intermolecular Michael Reaction of Aldehydes with Enones;189 1.10.4.2.1.3;1.1.4.2.1.3 Intermolecular Michael/Acetalization Reaction of Aldehydes with Quinones;192 1.10.4.2.1.4;1.1.4.2.1.4 Intermolecular Michael Reaction of Aldehydes with Enals;193 1.10.4.2.1.5;1.1.4.2.1.5 Intermolecular Michael Reaction of Ketones with a,ß-Unsaturated Esters;194 1.10.4.2.1.6;1.1.4.2.1.6 Intermolecular One-Pot Knoevenagel/Michael Reaction of Ketones with a,ß-Unsaturated Esters;196 1.10.4.2.1.7;1.1.4.2.1.7 Intermolecular Michael Reaction of Aldehydes with a,ß-Unsaturated Esters;197 1.10.4.2.1.8;1.1.4.2.1.8 Intermolecular Michael Reaction of Ketones with a,ß-Unsaturated