Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide.
• Critically evaluates the preparative applicability and significance of the synthetic methods.
• Discusses relevant background information and provides detailed experimental procedures

For full information on the Science of Synthesis series, visit the Science of Synthesis Homepage Series Editors: D. Bellus, S. V. Ley, R. Noyori, M. Regitz, E. Schaumann, I. Shinkai, E. J. Thomas, B. M. Trost, P. J. Reider.

1;Science of Synthesis - Volume 14: Six-Membered Hetarenes with One Chalcogen;1 1.1;Title page;3 1.2;Imprint;5 1.3;Preface;6 1.4;Volume Editor's Preface;8 1.5;Overview;10 1.6;Table of Contents;12 1.7;Introduction;54 1.8;14.1 Product Class 1: Pyrylium Salts;64 1.8.1;14.1.1 Synthesis by Ring-Closure Reactions;78 1.8.1.1;14.1.1.1 By Formation of One O--C and Two C--C Bonds;78 1.8.1.1.1;14.1.1.1.1 Method 1: [C1 + C3 + C1] Diacylation of Propene and Higher Alkenes;78 1.8.1.1.1.1;14.1.1.1.1.1 Variation 1: Diacylation of Acyclic Propene Derivatives;78 1.8.1.1.1.2;14.1.1.1.1.2 Variation 2: Diacylation of Aryl-Substituted Alkenes;90 1.8.1.1.1.3;14.1.1.1.1.3 Variation 3: Diacylation of 1-Methylcycloalkenes or Methylenecycloalkanes;94 1.8.1.1.1.4;14.1.1.1.1.4 Variation 4: Diacylation of Cycloalkenes;95 1.8.1.1.1.5;14.1.1.1.1.5 Variation 5: Triacylation of Alkenes;96 1.8.1.1.2;14.1.1.1.2 Method 2: [C2 + C1 + C2] Condensation of Methyl(ene) Ketones or Their Equivalents with Aldehydes, Orthoesters, or Their Derivatives;97 1.8.1.1.2.1;14.1.1.1.2.1 Variation 1: Condensation of Methyl(ene) Ketones with Aldehydes by Dehydrocyclization;100 1.8.1.1.2.2;14.1.1.1.2.2 Variation 2: Pyrylium Salts from Methyl(ene) Ketones and Aldehyde Derivatives (Acetals, Acylals);108 1.8.1.1.2.3;14.1.1.1.2.3 Variation 3: Condensation of Methyl(ene) Ketones with Orthoesters;110 1.8.1.1.2.4;14.1.1.1.2.4 Variation 4: Condensation of Alkynes with Aldehydes;114 1.8.1.1.3;14.1.1.1.3 Method 3: [C2 + C2 + C1] Condensation of Methyl(ene) Ketones or Their Equivalents with Carboxylic Acid Derivatives;115 1.8.1.1.3.1;14.1.1.1.3.1 Variation 1: Condensation of Aryl Methyl Ketones with Carboxylic Acid Derivatives;115 1.8.1.1.3.2;14.1.1.1.3.2 Variation 2: Condensation of a-Oxo Carboxylic Esters with Benzaldehydes;119 1.8.1.1.3.3;14.1.1.1.3.3 Variation 3: From Alkynes and Carboxylic Acid Derivatives;119 1.8.1.1.3.4;14.1.1.1.3.4 Variation 4: Acylation of Aromatic Hydrocarbons, Aromatic Heterocycles, or Phenol Ethers;120 1.8.1.2;14.1.1.2 By Formation of One O--C and One C--C Bond;121 1.8.1.2.1;14.1.1.2.1 Method 1: [C3 + C2] Condensation of Methyl(ene) Ketones or Their Synthetic Equivalents with 1,3-Dicarbonyl Compounds, a,ß-Unsaturated Oxo Compounds, or Their Synthetic Equivalents;121 1.8.1.2.1.1;14.1.1.2.1.1 Variation 1: From Methyl(ene) Ketones and 1,3-Dicarbonyl Compounds;121 1.8.1.2.1.2;14.1.1.2.1.2 Variation 2: From Methyl(ene) Ketones and Enols or Other Derivatives of 1,3-Dicarbonyl Compounds;123 1.8.1.2.1.3;14.1.1.2.1.3 Variation 3: From Methyl(ene) Ketones or Their Synthetic Equivalents and ß-Oxo Aldehydes or Their Synthetic Equivalents;128 1.8.1.2.1.4;14.1.1.2.1.4 Variation 4: From Methyl(ene) Ketones and a,ß-Unsaturated Ketones Followed by Dehydrocyclization;135 1.8.1.2.1.5;14.1.1.2.1.5 Variation 5: Directly from Two Equivalents of a,ß-Unsaturated Ketones;148 1.8.1.2.1.6;14.1.1.2.1.6 Variation 6: From a,ß-Unsaturated Ketones and 1,3-Diketones, 3-Oxo Esters, or a-Acyloxy Ketones;148 1.8.1.2.1.7;14.1.1.2.1.7 Variation 7: From a,ß-Unsaturated Ketones and Cyclic Ketones;149 1.8.1.2.1.8;14.1.1.2.1.8 Variation 8: From Methyl(ene) Ketones or Their Synthetic Equivalents and 2-Benzylidenecyclohexanone Derivatives;152 1.8.1.2.1.9;14.1.1.2.1.9 Variation 9: From Ketones or Their Synthetic Equivalents and ß-Chloro-a,ß-unsaturated Ketones or Aldehydes;155 1.8.1.2.1.10;14.1.1.2.1.10 Variation 10: From Alkynes and a,ß-Unsaturated Ketones;157 1.8.1.2.1.11;14.1.1.2.1.11 Variation 11: From Benzil and Cyclopentadiene;158 1.8.1.2.1.12;14.1.1.2.1.12 Variation 12: 2,4,6-Triarylpyrylium Perchlorates from 1,3-Diarylpropane-1,3-diones by Cleavage of an Aroyl Group;158 1.8.1.2.2;14.1.1.2.2 Method 2: [C4 + C1] Forming a C5-Chain from Two Synthons;159 1.8.1.2.2.1;14.1.1.2.2.1 Variation 1: From a,ß- or ß,.-Unsaturated Ketones and Carboxylic Acid Derivatives;159 1.8.1.2.2.2;14.1.1.2.2.2 Variation 2: Condensation of 1,3-Diketones with Orthoformates;165 1.8.1.2.2.3;14.1.1