Turning Information into Knowledge

Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

Features:

• Contains the expertise of presently 450 leading chemists worldwide.
• Critically evaluates the preparative applicability and significance of the synthetic methods.
• Discusses relevant background information and provides detailed experimental procedures

1;Science of Synthesis - Volume 3: Compounds of Groups 12 and 11 (Zn, Cd, Hg, Cu, Ag, Au);1 1.1;Title page;3 1.2;Imprint;5 1.3;Preface;6 1.4;Overview;9 1.5;Table of Contents;10 1.6;Introduction;28 1.7;3.1 Product Class 1: Organometallic Complexes of Zinc;32 1.7.1;3.1.1 Product Subclass 1: Zinc--Aryl Complexes;34 1.7.1.1;Synthesis of Product Subclass 1;34 1.7.1.1.1;3.1.1.1 Method 1: Diarylzincs by Transmetalation of an Organometallic Reagent with a Zinc Halide;34 1.7.1.1.1.1;3.1.1.1.1 Variation 1: From an Arylmagnesium Reagent;35 1.7.1.1.1.2;3.1.1.1.2 Variation 2: From a Preformed Aryllithium Reagent;35 1.7.1.1.1.3;3.1.1.1.3 Variation 3: From an In Situ Generated Aryllithium Reagent;36 1.7.1.1.2;3.1.1.2 Method 2: Diarylzincs by Transmetalation of a Triarylborane with a Dialkylzinc;37 1.7.1.1.3;3.1.1.3 Method 3: Diarylzincs by Transmetalation of a Diarylmercury with Zinc;37 1.7.1.1.4;3.1.1.4 Method 4: Arylzinc Halides by Transmetalation of an Organometallic Reagent with a Zinc Halide;38 1.7.1.1.4.1;3.1.1.4.1 Variation 1: From an In Situ Generated Arylnickel Reagent;38 1.7.1.1.4.2;3.1.1.4.2 Variation 2: From an Arylmagnesium Reagent;39 1.7.1.1.4.3;3.1.1.4.3 Variation 3: From an Aryllithium Reagent;39 1.7.1.1.5;3.1.1.5 Method 5: Arylzinc Halides from an Aryl Halide and Zinc;40 1.7.1.1.5.1;3.1.1.5.1 Variation 1: Using Zinc Dust;40 1.7.1.1.5.2;3.1.1.5.2 Variation 2: Using Activated Zinc;41 1.7.1.1.5.3;3.1.1.5.3 Variation 3: Using a Zinc Anode;41 1.7.1.1.6;3.1.1.6 Methods 6: Additional Methods;42 1.7.1.2;Applications of Product Subclass 1 in Organic Synthesis;42 1.7.1.2.1;3.1.1.7 Method 7: Palladium-Catalyzed Aryl--Aryl Coupling;42 1.7.1.2.2;3.1.1.8 Method 8: Coupling with Acid Chlorides;43 1.7.2;3.1.2 Product Subclass 2: Zinc--Hetaryl Complexes;44 1.7.2.1;Synthesis of Product Subclass 2;44 1.7.2.1.1;3.1.2.1 Method 1: Hetarylzinc Halides by Transmetalation of an Organometallic Reagent with a Zinc Halide;44 1.7.2.1.2;3.1.2.2 Method 2: Hetarylzinc Halides from a Hetaryl Halide and Zinc;45 1.7.2.1.2.1;3.1.2.2.1 Variation 1: Using Zinc Dust;45 1.7.2.1.2.2;3.1.2.2.2 Variation 2: Using Activated Zinc;46 1.7.2.1.3;3.1.2.3 Methods 3: Additional Methods;47 1.7.2.2;Applications of Product Subclass 2 in Organic Synthesis;47 1.7.2.2.1;3.1.2.4 Method 4: Palladium-Catalyzed Cross-Coupling Reactions;47 1.7.3;3.1.3 Product Subclass 3: Zinc--(Het)arylmethyl Complexes;48 1.7.3.1;Synthesis of Product Subclass 3;48 1.7.3.1.1;3.1.3.1 Method 1: Dibenzylzincs by Transmetalation of an Organometallic Reagent with a Zinc Halide;49 1.7.3.1.2;3.1.3.2 Method 2: Dibenzylzincs by Transmetalation of a Tribenzylborane with a Dialkylzinc;49 1.7.3.1.3;3.1.3.3 Method 3: (Het)arylmethylzinc Halides from a (Het)arylmethyl Halide and Zinc;50 1.7.3.1.3.1;3.1.3.3.1 Variation 1: Using Zinc Dust;50 1.7.3.1.3.2;3.1.3.3.2 Variation 2: Using Activated Zinc;51 1.7.3.1.3.3;3.1.3.3.3 Variation 3: From an In Situ Generated Benzylic Halide and Zinc Dust;52 1.7.3.1.4;3.1.3.4 Method 4: (Het)arylmethylzinc Halides by the Methylene Homologation of a (Het)arylcopper;52 1.7.3.1.5;3.1.3.5 Methods 5: Additional Methods;53 1.7.3.2;Applications of Product Subclass 3 in Organic Synthesis;54 1.7.3.2.1;3.1.3.6 Method 6: 1,4-Addition to Michael Acceptors;54 1.7.4;3.1.4 Product Subclass 4: Zinc--Allenyl Complexes;55 1.7.4.1;Synthesis of Product Subclass 4;55 1.7.4.1.1;3.1.4.1 Method 1: Diallenylzincs by Transmetalation of an Organometallic Reagent with a Zinc Halide;55 1.7.4.1.2;3.1.4.2 Method 2: Propargylic Zinc Halides from a Propargylic Halide and Zinc;56 1.7.4.1.3;3.1.4.3 Method 3: Allenylzinc Halides by the Methylene Homologation of an Alkynyl Organometallic Reagent;56 1.7.4.1.4;3.1.4.4 Methods 4: Additional Methods;57 1.7.4.2;Applications of Product Subclass 4 in Organic Synthesis;58 1.7.4.2.1;3.1.4.5 Method 5: 1,2-Addition to Aldehydes, Ketones, or Imines;58 1.7.5;3.1.5 Product Subclass 5: Zinc--Allyl Complexes;58 1.7.5.1;Synthesis of Product Subcla