Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
• Critically evaluates the preparative applicability and significance of the synthetic methods
• Discusses relevant background information and provides detailed experimental procedures

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1;Science of Synthesis - Volume 38: Peroxides;1 1.1;Title page;3 1.2;Imprint;5 1.3;Preface;6 1.4;Overview;8 1.5;Table of Contents;10 1.6;Introduction;28 1.7;38.1 Product Class 1: Alkyl and Cycloalkyl Hydroperoxides;36 1.7.1;38.1.1 Product Subclass 1: a-Unsubstituted Alkyl Hydroperoxides;36 1.7.1.1;38.1.1.1 Synthesis of Product Subclass 1;37 1.7.1.1.1;38.1.1.1.1 Method 1: Reactions of Alkanes with Molecular Oxygen;37 1.7.1.1.2;38.1.1.1.2 Method 2: Hydrolysis of Alkyl Metal and Alkyl Metalloid Peroxides;38 1.7.1.1.2.1;38.1.1.1.2.1 Variation 1: Via Oxidation of Alkylmagnesium Halides with Molecular Oxygen;38 1.7.1.1.2.2;38.1.1.1.2.2 Variation 2: Via Oxidation of Alkylboron Halides with Molecular Oxygen;39 1.7.1.1.3;38.1.1.1.3 Method 3: Reaction of Oxetanes with Hydrogen Peroxide;40 1.7.1.1.4;38.1.1.1.4 Method 4: Reaction of Epoxides with Hydrogen Peroxide;41 1.7.1.1.4.1;38.1.1.1.4.1 Variation 1: Catalyzed by Methyltrioctylammonium Tetrakis(oxodiperoxotungsto)phosphate;42 1.7.1.1.5;38.1.1.1.5 Method 5: Reaction of Alkyl Halides;43 1.7.1.1.5.1;38.1.1.1.5.1 Variation 1: With Hydrogen Peroxide in the Presence of Silver(I) Trifluoroacetate;43 1.7.1.1.5.2;38.1.1.1.5.2 Variation 2: With 2-Alkoxypropan-2-yl and 2-(2-Methoxyethoxy)propan-2-yl Hydroperoxides;44 1.7.1.1.5.3;38.1.1.1.5.3 Variation 3: With Potassium Superoxide;45 1.7.1.1.6;38.1.1.1.6 Method 6: Reaction of Alcohols with Hydrogen Peroxide;46 1.7.1.1.6.1;38.1.1.1.6.1 Variation 1: Without Catalysts;46 1.7.1.1.6.2;38.1.1.1.6.2 Variation 2: With Acid Catalysis;47 1.7.1.1.7;38.1.1.1.7 Method 7: Reaction of Dialkyl Sulfates with Hydrogen Peroxide;47 1.7.1.1.8;38.1.1.1.8 Method 8: Reaction of Alkyl Methanesulfonates with Hydrogen Peroxide;48 1.7.1.1.8.1;38.1.1.1.8.1 Variation 1: Reaction of Homoallylic Methanesulfonates with Hydrogen Peroxide;49 1.7.1.1.8.2;38.1.1.1.8.2 Variation 2: Reaction of Cyclic Homoallylic 4-Bromobenzenesulfonates with Hydrogen Peroxide;50 1.7.1.1.9;38.1.1.1.9 Method 9: Reaction of 1-Substituted 1-Sulfonylhydrazines with Molecular Oxygen under Basic Conditions;50 1.7.1.1.10;38.1.1.1.10 Method 10: Reaction of 1-Alkyl-2-tosylhydrazines with Hydrogen Peroxide and Sodium Peroxide;51 1.7.1.1.11;38.1.1.1.11 Method 11: Synthesis from Alkenes;52 1.7.1.1.11.1;38.1.1.1.11.1 Variation 1: With Triethylsilane and Oxygen with a Cobalt(II) Catalyst;53 1.7.1.1.11.2;38.1.1.1.11.2 Variation 2: Photooxygenation with Methylene Blue Sensitizer;54 1.7.1.1.11.3;38.1.1.1.11.3 Variation 3: Photooxygenation with 4-Chlorobenzenethiol;55 1.7.1.1.11.4;38.1.1.1.11.4 Variation 4: With N-Bromosuccinimide and Hydrogen Peroxide;55 1.7.1.1.11.5;38.1.1.1.11.5 Variation 5: With 1,3-Dibromo-5,5-dimethylhydantoin and Hydrogen Peroxide;56 1.7.1.1.12;38.1.1.1.12 Method 12: Synthesis from Conjugated Dienes;57 1.7.1.1.13;38.1.1.1.13 Method 13: Synthesis from Peroxy Esters;57 1.7.1.2;38.1.1.2 Applications of Product Subclass 1 in Organic Synthesis;58 1.7.2;38.1.2 Product Subclass 2: a-Halogen-Substituted Alkyl Hydroperoxides;58 1.7.2.1;38.1.2.1 Synthesis of Product Subclass 2;59 1.7.2.1.1;38.1.2.1.1 a-Fluoroalkyl Hydroperoxides;59 1.7.2.1.1.1;38.1.2.1.1.1 Method 1: Decomposition of Hexafluoroacetone Perhydrate;59 1.7.2.1.1.2;38.1.2.1.1.2 Method 2: Reaction of Perfluoroperoxy Derivatives with Water;59 1.7.2.1.2;38.1.2.1.2 a-Chloroalkyl Hydroperoxides;60 1.7.2.1.2.1;38.1.2.1.2.1 Method 1: Reaction of Chloroalkenes with Ozone;60 1.7.3;38.1.3 Product Subclass 3: a-Oxygen-Substituted Alkyl Hydroperoxides;61 1.7.3.1;38.1.3.1 Synthesis of Product Subclass 3;61 1.7.3.1.1;38.1.3.1.1 a-Hydroxyalkyl Hydroperoxides;61 1.7.3.1.1.1;38.1.3.1.1.1 Method 1: Reaction of Aldehydes with Hydrogen Peroxide and Iodine;61 1.7.3.1.1.2;38.1.3.1.1.2 Method 2: Reaction of a-Halo Ketones with Hydrogen Peroxide;62 1.7.3.1.2;38.1.3.1.2 a-Alkoxyalkyl Hydroperoxides;63 1.7.3.1.2.1;38.1.3.1.2.1 Method 1: Ozonolysis of Alkenes;63 1.7.3.1.2.2;38.1.3.1.2.2 Method 2: Reaction of Vinyl Ethers wit