Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
• Critically evaluates the preparative applicability and significance of the synthetic methods
• Discusses relevant background information and provides detailed experimental procedures

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1;Science of Synthesis - Volume 45b: Aromatic Ring Assemblies, Polycyclic Aromatic Hydrocarbons, and Conjugated Polyenes;1 1.1;Title page;3 1.2;Imprint;5 1.3;Preface;6 1.4;Overview;8 1.5;Table of Contents;10 1.6;45.13 Product Class 13: Biaryls;40 1.6.1;45.13.1 Synthesis of Product Class 13;40 1.6.1.1;45.13.1.1 Synthesis Using Copper Catalysis;40 1.6.1.1.1;45.13.1.1.1 Method 1: The Ullmann Reaction;40 1.6.1.1.2;45.13.1.1.2 Method 2: Cross-Coupling Reactions;42 1.6.1.1.2.1;45.13.1.1.2.1 Variation 1: Using Boronic Acids;42 1.6.1.1.2.2;45.13.1.1.2.2 Variation 2: Using Organotin Reagents;43 1.6.1.2;45.13.1.2 The Suzuki Cross-Coupling Reaction;44 1.6.1.2.1;45.13.1.2.1 Method 1: Aryl Iodides in Suzuki Cross-Coupling Reactions;45 1.6.1.2.2;45.13.1.2.2 Method 2: Aryl Bromides in Suzuki Cross-Coupling Reactions;48 1.6.1.2.3;45.13.1.2.3 Method 3: Aryl Chlorides in Suzuki Cross-Coupling Reactions;55 1.6.1.2.4;45.13.1.2.4 Method 4: Aryl 4-Toluenesulfonates and Trifluoromethanesulfonates in Suzuki Cross-Coupling Reactions;60 1.6.1.2.5;45.13.1.2.5 Method 5: Diazonium Salts in Suzuki Cross-Coupling Reactions;64 1.6.1.2.6;45.13.1.2.6 Method 6: Synthesis of Hindered Biaryls Using the Suzuki Cross-Coupling Reaction;65 1.6.1.2.7;45.13.1.2.7 Method 7: Synthesis of Oligoaromatics Using the Suzuki Cross-Coupling Reaction;68 1.6.1.3;45.13.1.3 The Stille Cross-Coupling Reaction;70 1.6.1.3.1;45.13.1.3.1 Method 1: Aryl Iodides in Stille Cross-Coupling Reactions;71 1.6.1.3.2;45.13.1.3.2 Method 2: Aryl Bromides in Stille Cross-Coupling Reactions;72 1.6.1.3.3;45.13.1.3.3 Method 3: Aryl Chlorides in Stille Cross-Coupling Reactions;73 1.6.1.3.4;45.13.1.3.4 Method 4: Aryl Trifluoromethanesulfonates in Stille Cross-Coupling Reactions;74 1.6.1.3.5;45.13.1.3.5 Method 5: Synthesis of Hindered Biaryls Using the Stille Cross-Coupling Reaction;75 1.6.1.4;45.13.1.4 The Negishi Cross-Coupling Reaction;77 1.6.1.4.1;45.13.1.4.1 Method 1: Aryl Iodides in Negishi Cross-Coupling Reactions;77 1.6.1.4.2;45.13.1.4.2 Method 2: Aryl Bromides in Negishi Cross-Coupling Reactions;79 1.6.1.4.3;45.13.1.4.3 Method 3: Aryl Chlorides in Negishi Cross-Coupling Reactions;80 1.6.1.4.4;45.13.1.4.4 Method 4: Aryl Trifluoromethanesulfonates in Negishi Cross-Coupling Reactions;81 1.6.1.4.5;45.13.1.4.5 Method 5: Synthesis of Hindered Biaryls Using the Negishi Cross-Coupling Reaction;82 1.6.1.5;45.13.1.5 The Hiyama Cross-Coupling Reaction;84 1.6.1.5.1;45.13.1.5.1 Method 1: Aryl Iodides in Hiyama Cross-Coupling Reactions;84 1.6.1.5.2;45.13.1.5.2 Method 2: Aryl Bromides in Hiyama Cross-Coupling Reactions;87 1.6.1.5.3;45.13.1.5.3 Method 3: Aryl Chlorides in Hiyama Cross-Coupling Reactions;89 1.6.1.5.4;45.13.1.5.4 Method 4: Aryl Trifluoromethanesulfonates in Hiyama Cross-Coupling Reactions;91 1.6.1.5.5;45.13.1.5.5 Method 5: Synthesis of Oligoaromatics Using the Hiyama Cross-Coupling Reaction;92 1.6.1.6;45.13.1.6 The Kumada--Corriu Cross-Coupling Reaction;92 1.6.1.6.1;45.13.1.6.1 Method 1: Aryl Iodides in Kumada--Corriu Cross-Coupling Reactions;92 1.6.1.6.2;45.13.1.6.2 Method 2: Aryl Bromides in Kumada--Corriu Cross-Coupling Reactions;94 1.6.1.6.3;45.13.1.6.3 Method 3: Aryl Chlorides in Kumada--Corriu Cross-Coupling Reactions;95 1.6.1.6.4;45.13.1.6.4 Method 4: Aryl Trifluoromethanesulfonates and Arenesulfonates in Kumada--Corriu Cross-Coupling Reactions;96 1.6.1.6.5;45.13.1.6.5 Method 5: Synthesis of Hindered Biaryls Using the Kumada--Corriu Cross-Coupling Reaction;98 1.6.1.6.6;45.13.1.6.6 Method 6: Synthesis of Oligoaromatics Using the Kumada--Corriu Coupling Reaction;98 1.6.1.7;45.13.1.7 Direct Arylation;99 1.6.1.7.1;45.13.1.7.1 Method 1: Intramolecular Direct Arylation;99 1.6.1.7.2;45.13.1.7.2 Method 2: Intermolecular Direct Arylation;105 1.6.1.7.2.1;45.13.1.7.2.1 Variation 1: In the Presence of Directing Groups;105 1.6.1.7.2.2;45.13.1.7.2.2 Variation 2: Without Directing Groups;110 1.6.1.7.3;45.13.1.7.3 Method 3: Palladium-Catalyzed Domino/Cascade Re