The Science of Synthesis Editorial Board, together with the volume editors and authors, is constantly reviewing the whole field of synthetic organic chemistry as presented in Science of Synthesis and evaluating significant developments in synthetic methodology. Four annual volumes updating content across all categories ensure that you always have access to state-of-the-art synthetic methodology.

1;Science of Synthesis Knowledge Updates 2016/3;1 2;Title Page;6 3;Copyright;8 4;Preface;9 5;Abstract;11 6;Science of Synthesis Knowledge Updates 2016/3;13 7;Table of Contents;15 8;10.22 Product Class 22: Azaindoles and Their Derivatives;23 9;10.22.1 Product Subclass 1: Azaindoles;23 9.1;10.22.1.1 Synthesis by Ring-Closure Reactions;34 9.1.1;10.22.1.1.1 By Annulation to a Pyridine;34 9.1.1.1;10.22.1.1.1.1 By Formation of One N-C and One C-C Bond;34 9.1.1.1.1;10.22.1.1.1.1.1 With Formation of 1-2 and 3-3a Bonds;34 9.1.1.1.1.1;10.22.1.1.1.1.1.1 Method 1: From Pyridylhydrazones (Fischer Synthesis);34 9.1.1.1.1.1.1;10.22.1.1.1.1.1.1.1 Variation 1: Indolization with Pyridinium Hydrochloride;39 9.1.1.1.1.1.2;10.22.1.1.1.1.1.1.2 Variation 2: From (6-Methoxypyridin-3-yl)hydrazine or (2-Methoxypyridin- 3-yl)hydrazine;40 9.1.1.1.1.1.3;10.22.1.1.1.1.1.1.3 Variation 3: Using Microwave Activation;44 9.1.1.1.1.1.4;10.22.1.1.1.1.1.1.4 Variation 4: From a Pyridin-4-yldiazonium N-Oxide and a ?-Oxo Acid;45 9.1.1.1.1.1.5;10.22.1.1.1.1.1.1.5 Variation 5: From a Pyridylhydrazine and an Enamine;46 9.1.1.1.1.1.6;10.22.1.1.1.1.1.1.6 Variation 6: From a Pyridylhydrazine and a ?-Halo Ketone (Grandberg Synthesis);47 9.1.1.1.1.1.7;10.22.1.1.1.1.1.1.7 Variation 7: From 4-Hydrazino-6-methylpyridin-2(1H)-one;48 9.1.1.1.1.1.8;10.22.1.1.1.1.1.1.8 Variation 8: From a Pyridylboronic Acid and Di-tert-butyl Azodicarboxylate;49 9.1.1.1.1.2;10.22.1.1.1.1.1.2 Method 2: From ortho-Substituted Nitropyridines (Bartoli Synthesis);53 9.1.1.1.1.3;10.22.1.1.1.1.1.3 Method 3: From N-Chloropyridin-2-amines and ?-Alkylsulfanyl Ketones (Gassman Synthesis);57 9.1.1.1.1.4;10.22.1.1.1.1.1.4 Method 4: From Pyridinamines and ?-Hydroxy Ketones (Bischler Synthesis);58 9.1.1.1.1.5;10.22.1.1.1.1.1.5 Method 5: From Halopyridin-2-amines and Alkynes (Larock Synthesis);62 9.1.1.1.1.6;10.22.1.1.1.1.1.6 Method 6: From Enamines of Pyridyl Ketones/Aldehydes;74 9.1.1.1.1.7;10.22.1.1.1.1.1.7 Method 7: From Iodopyridinamines and Allyl Acetate;78 9.1.1.1.1.8;10.22.1.1.1.1.1.8 Method 8: From Nitropyridines and Alkynes;80 9.1.1.1.2;10.22.1.1.1.1.2 With Formation of 1-2 and 2-3 Bonds;81 9.1.1.1.2.1;10.22.1.1.1.1.2.1 Method 1: From an Alkyl-N-(tert-Butoxycarbonyl)pyridinamine and an Amide;81 9.1.1.1.2.1.1;10.22.1.1.1.1.2.1.1 Variation 1: From an Unprotected Alkylpyridinamine and an Ester;89 9.1.1.1.2.2;10.22.1.1.1.1.2.2 Method 2: From a 2-Aminopyridine-3-carbaldehyde and a Diazo Ester;90 9.1.1.1.2.3;10.22.1.1.1.1.2.3 Method 3: From a Methylpyridinamine and the Vilsmeier Reagent;91 9.1.1.1.3;10.22.1.1.1.1.3 With Formation of 1-7a and 2-3 Bonds;92 9.1.1.1.3.1;10.22.1.1.1.1.3.1 Method 1: From an Alkylpyridine and a Nitrile;92 9.1.1.1.3.1.1;10.22.1.1.1.1.3.1.1 Variation 1: From a 2-Fluoro(alkyl)pyridine and a Nitrile;93 9.1.1.1.3.2;10.22.1.1.1.1.3.2 Method 2: From a 2-(2-Chloropyridin-3-yl)oxirane and an Amine;94 9.1.1.1.3.3;10.22.1.1.1.1.3.3 Method 3: From a 2-Halopyridyl Aldehyde and Ethyl Isocyanoacetate;96 9.1.1.1.4;10.22.1.1.1.1.4 With Formation of 1-2 and 1-7a Bonds;97 9.1.1.1.4.1;10.22.1.1.1.1.4.1 Method 1: From a 2-Chloro-3-(2-chloroethyl)pyridine and an Amine;97 9.1.1.1.4.1.1;10.22.1.1.1.1.4.1.1 Variation 1: From 3-(2-{[(Trifluoromethyl)sulfonyl]oxy}ethyl)pyridine- 2,6-diyl Bis(trifluoromethanesulfonate) and an Amine;99 9.1.1.1.4.2;10.22.1.1.1.1.4.2 Method 2: From a 2-Bromo-3-(2-bromoalkenyl)pyridine and an Amine;101 9.1.1.1.4.3;10.22.1.1.1.1.4.3 Method 3: From a 2-Alkynyl-3-bromopyridine and a Carbamate;103 9.1.1.2;10.22.1.1.1.2 By Formation of One N-C Bond;103 9.1.1.2.1;10.22.1.1.1.2.1 With Formation of the 1-2 Bond;103 9.1.1.2.1.1;10.22.1.1.1.2.1.1 Method 1: From (3-Nitropyridin-2-yl)pyruvates (Reissert Synthesis);103 9.1.1.2.1.2;10.22.1.1.1.2.1.2 Method 2: From a Halopyridinamine and an Enolate;111 9.1.1.2.1.3;10.22.1.1.1.2.1.3 Method 3: From Alkynylpyridinamines;114 9.1.1.2.1.3.1;10.22.1.1.1.2.1.3.1 Variation 1: Base-Mediated Cyclization;114 9.1.1.2.1.3.2;10.22.1.1.1.2.1.3.2 Variation 2: Usi