The Science of Synthesis Editorial Board, together with the volume editors and authors, is constantly reviewing the whole field of synthetic organic chemistry as presented in Science of Synthesis and evaluating significant developments in synthetic methodology. Several annual volumes updating content across all categories ensure that you always have access to state-of-the-art synthetic methodology.

1;Science of Synthesis: Knowledge Updates 2018/2;1 2;Title Page;7 3;Copyright;8 4;Preface;9 5;Abstracts;11 6;Overview;13 7;Table of Contents;15 8;10.23 Product Class 23: Pyrido[X,Y-b]indoles (Carbolines);33 8.1;10.23.1 Product Subclass 1: 9H-Pyrido[2,3-b]indoles (?-Carbolines);38 8.1.1;10.23.1.1 Synthesis by Ring-Closure Reactions;38 8.1.1.1;10.23.1.1.1 By Annulation to an Arene;38 8.1.1.1.1;10.23.1.1.1.1 By Formation of Four N-C and Two C-C Bonds;38 8.1.1.1.1.1;10.23.1.1.1.1.1 With Formation of 1-2, 2-3, 4-4a, 1-9a, 8a-9, and 9-9a Bonds;38 8.1.1.1.1.1.1;10.23.1.1.1.1.1.1 Method 1: From 1-Bromo-2-(2,2-dibromovinyl)benzenes, Ammonia, and Alkyl Aldehydes;38 8.1.1.1.2;10.23.1.1.1.2 By Formation of Two N-C and One C-C Bonds;40 8.1.1.1.2.1;10.23.1.1.1.2.1 With Formation of 1-9a, 4-4a, and 9-9a Bonds;40 8.1.1.1.2.1.1;10.23.1.1.1.2.1.1 Method 1: From (2-Nitroaryl)acetonitriles and 3-Acetoxy-3-aryl-2-methylene Ketones;40 8.1.1.1.2.1.2;10.23.1.1.1.2.1.2 Method 2: From (2-Nitrophenyl)acetonitrile and 3-Arylenones;42 8.1.1.1.2.1.2.1;10.23.1.1.1.2.1.2.1 Variation 1: From (2-Nitrophenyl)acetonitrile and 4H-1-Benzopyran-4-ones;44 8.1.1.1.3;10.23.1.1.1.3 By Formation of Two N-C Bonds;45 8.1.1.1.3.1;10.23.1.1.1.3.1 With Formation of 8a-9 and 9-9a Bonds;45 8.1.1.1.3.1.1;10.23.1.1.1.3.1.1 Method 1: From Primary Amines and 3-(2-Bromophenyl)-2-chloropyridine;45 8.1.1.1.4;10.23.1.1.1.4 By Formation of One N-C Bond and One C-C Bond;47 8.1.1.1.4.1;10.23.1.1.1.4.1 With Formation of 4a-4b and 9-9a Bonds;47 8.1.1.1.4.1.1;10.23.1.1.1.4.1.1 Method 1: From 2,3-Dihalopyridines and Anilines;47 8.1.1.1.4.1.2;10.23.1.1.1.4.1.2 Method 2: From 2-Iodopyridine and a 2-Bromoaniline;48 8.1.1.1.5;10.23.1.1.1.5 By Formation of Two C-C Bonds;49 8.1.1.1.5.1;10.23.1.1.1.5.1 With Formation of 3-4 and 4a-9a Bonds;49 8.1.1.1.5.1.1;10.23.1.1.1.5.1.1 Method 1: From (2-Alkenylaryl)carbodiimides;49 8.1.1.1.5.1.2;10.23.1.1.1.5.1.2 Method 2: From N-Acyl-N-(2-alkynylaryl)pyrimidin-2-amines or 3-[(2-Alkynylphenyl)amino]pyrazin-2-ones;51 8.1.1.1.6;10.23.1.1.1.6 By Formation of One N-C Bond;53 8.1.1.1.6.1;10.23.1.1.1.6.1 With Formation of the 9-9a Bond;53 8.1.1.1.6.1.1;10.23.1.1.1.6.1.1 Method 1: From 3-(2-Azidoaryl)pyridines;53 8.1.1.1.6.1.1.1;10.23.1.1.1.6.1.1.1 Variation 1: From 3-(2-Azidoaryl)pyridinium Trifluoromethanesulfonates and a Rhodium Catalyst;54 8.1.1.1.6.1.2;10.23.1.1.1.6.1.2 Method 2: From 3-(2-Nitroaryl)pyridines;55 8.1.1.1.6.1.2.1;10.23.1.1.1.6.1.2.1 Variation 1: From 3-(2-Nitrosoaryl)pyridines;56 8.1.1.1.6.1.3;10.23.1.1.1.6.1.3 Method 3: From 2-(3-Pyridyl)-N-tosylanilines or N-Acetyl-2-(3-pyridyl)-anilines;56 8.1.1.1.6.1.4;10.23.1.1.1.6.1.4 Method 4: From N-[2-(2-Fluoropyridin-3-yl)phenyl]pivalamide;58 8.1.1.1.7;10.23.1.1.1.7 By Formation of One C-C Bond;58 8.1.1.1.7.1;10.23.1.1.1.7.1 With Formation of the 4a-4b Bond;58 8.1.1.1.7.1.1;10.23.1.1.1.7.1.1 Method 1: From N-Arylpyridin-2-amines;58 8.1.1.1.7.1.1.1;10.23.1.1.1.7.1.1.1 Variation 1: From N,N-Diphenylpyridin-2-amine or N-Methyl-N-phenylpyridin-2-amine;59 8.1.1.1.7.1.2;10.23.1.1.1.7.1.2 Method 2: From N2-Phenylpyridine-2,3-diamines;60 8.1.1.1.7.1.3;10.23.1.1.1.7.1.3 Method 3: From an N-Arylpyridin-2-amine with at Least One Halogen on at Least One Ring;61 8.1.1.1.7.1.3.1;10.23.1.1.1.7.1.3.1 Variation 1: From N-Aryl-3-chloropyridin-2-amines by Palladium Catalysis;61 8.1.1.1.7.1.3.2;10.23.1.1.1.7.1.3.2 Variation 2: From N-Aryl-3-bromopyridin-2-amines with Palladium Catalysis;62 8.1.1.1.7.1.3.3;10.23.1.1.1.7.1.3.3 Variation 3: From N-[3-Chloro-1-methylpyridin-2(1H)-ylidene]anilines;65 8.1.1.1.7.1.3.4;10.23.1.1.1.7.1.3.4 Variation 4: From N-(Chloroaryl)-3-chloro-1-methylpyridin-2(1H)-imines and Secondary Amines;66 8.1.1.1.7.1.3.5;10.23.1.1.1.7.1.3.5 Variation 5: From N-Aryl-3-halopyridin-2-amines by Photostimulated SRN1 Reactions;69 8.1.1.1.7.1.3.6;10.23.1.1.1.7.1.3.6 Variation 6: From 3-Bromo-N-(2-bromophenyl)pyridin-2-amines by Palladium(0)-Catalyzed Bond Formation via Tributylstannyl Intermediates;71 8.1.1.2;10