The major emphasis here is on enantioselective reactions using asymmetric catalysts. Examples from the total synthesis of various natural and unnatural targets validates the utility of the synthetic methods. Specific topics discussed: cycloaddition, cycloisomerization and sigmatropic rearrangement reactions, allylic and carbonyl functionalization reactions, metal-catalyzed cross-coupling reactions, desymmetrization, fluorination, polymerization and sulfide oxidation reactions.

This volume is part of a 3-volume set: Science of Synthesis Stereoselective Synthesis Workbench Edition

Further information about Stereoselective Synthesis (including sample pages and the table of contents)

1;Science of Synthesis: Stereoselective Synthesis 3 - Stereoselective Pericyclic Reactions, Cross Coupling, and C-H and C-X Activation;1 1.1;Organizational Structure of Science of Synthesis;2 1.2;Science of Synthesis Reference Library;3 1.3;Title page;5 1.4;Imprint;7 1.5;Preface;8 1.6;Volume Editors' Preface;10 1.7;Stereoselective Synthesis Volumes;12 1.8;Abstracts;14 1.9;Overview;26 1.10;Table of Contents;28 1.11;Introduction;52 1.12;3.1 [m + n]-Cycloaddition Reactions (Excluding [4 + 2]);58 1.12.1;3.1.1 [2 + 2]-Cycloaddition Reactions;59 1.12.1.1;3.1.1.1 [2 + 2] Cycloadditions Catalyzed by Transition Metals;59 1.12.1.1.1;3.1.1.1.1 Chiral Titanium Catalysts;59 1.12.1.1.2;3.1.1.1.2 Chiral Copper Catalysts;61 1.12.1.1.3;3.1.1.1.3 Chiral Rhodium Catalysts;62 1.12.1.1.4;3.1.1.1.4 Chiral Iridium Catalysts;63 1.12.1.2;3.1.1.2 [2 + 2] Cycloadditions Catalyzed by Organic Molecules;65 1.12.1.2.1;3.1.1.2.1 Lectka's Quinine-Derived Catalysts;65 1.12.1.2.2;3.1.1.2.2 Fu's 4-Pyrrolidinopyridine Catalysts;67 1.12.1.2.2.1;3.1.1.2.2.1 Asymmetric Staudinger Synthesis of ß-Lactams;67 1.12.1.2.2.2;3.1.1.2.2.2 [2 + 2] Cycloadditions of Disubstituted Ketenes with Aldehydes;68 1.12.1.2.2.3;3.1.1.2.2.3 [2 + 2] Cycloadditions of Ketenes with Azo Compounds;69 1.12.1.2.2.4;3.1.1.2.2.4 [2 + 2] Cycloadditions of Ketenes with Nitroso Compounds;70 1.12.1.2.3;3.1.1.2.3 Corey's Oxazaborolidine Catalysts;71 1.12.1.2.4;3.1.1.2.4 Ye's N-Heterocyclic Carbene Catalysts;73 1.12.1.2.4.1;3.1.1.2.4.1 N-Heterocyclic Carbene Catalyzed Staudinger Reaction of Ketenes;73 1.12.1.2.4.2;3.1.1.2.4.2 N-Heterocyclic Carbene Catalyzed [2 + 2] Cycloadditions of Disubstituted Ketenes with 2-Oxoaldehydes;74 1.12.1.2.4.3;3.1.1.2.4.3 N-Heterocyclic Carbene Catalyzed [2 + 2] Cycloadditions of Ketenes with Ketones;75 1.12.1.2.4.4;3.1.1.2.4.4 N-Heterocyclic Carbene Catalyzed [2 + 2] Cycloadditions of Ketenes with Azodicarboxylates;76 1.12.2;3.1.2 [3 + 2]-Cycloaddition Reactions;77 1.12.2.1;3.1.2.1 Phosphine-Catalyzed [3 + 2]-Cycloaddition Reactions of Allenoates with Dienophiles;78 1.12.2.1.1;3.1.2.1.1 Cycloaddition Reactions Catalyzed by P-Chiral 7-Phosphabicyclo[2.2.1]heptane;79 1.12.2.1.2;3.1.2.1.2 Cycloaddition Reactions Catalyzed by Binaphthyl-Derived Phosphines;80 1.12.2.1.3;3.1.2.1.3 Cycloaddition Reactions Catalyzed by Amino Acid Based Phosphines;82 1.12.2.1.4;3.1.2.1.4 Cycloaddition Reactions Catalyzed by Planar-Chiral 2-Phospha[3]ferrocenophanes;83 1.12.2.1.5;3.1.2.1.5 Cycloaddition Reactions Catalyzed by Chiral Thiourea-Containing Phosphines;84 1.12.2.2;3.1.2.2 Palladium-Catalyzed Asymmetric [3 + 2] Trimethylenemethane Cycloaddition Reactions;85 1.12.3;3.1.3 [4 + 1]-Cycloaddition Reactions;90 1.12.3.1;3.1.3.1 Rhodium- and Platinum-Catalyzed Asymmetric [4 + 1]-Cycloaddition Reactions of Vinylallenes and Carbon Monoxide;90 1.12.3.2;3.1.3.2 Copper-Catalyzed Asymmetric [4 + 1] Cycloadditions of Enones with Diazo Compounds;93 1.12.4;3.1.4 [3 + 3]-Cycloaddition Reactions;96 1.12.4.1;3.1.4.1 Chiral Lewis Acid Catalyzed [3 + 3] Cycloadditions of Nitrones to Doubly Activated Cyclopropanes;96 1.12.4.2;3.1.4.2 Palladium-Catalyzed Asymmetric [3 + 3] Cycloadditions of Trimethylenemethane Derivatives with Nitrones;98 1.12.5;3.1.5 [4 + 3]-Cycloaddition Reactions;99 1.12.5.1;3.1.5.1 Asymmetric Organocatalysis of [4 + 3]-Cycloaddition Reactions of Allylic Cations and Dienes;99 1.12.5.2;3.1.5.2 Chiral Lewis Acid Catalyzed [4 + 3] Cycloadditions of Nitrogen-Stabilized Oxyallyl Cations Derived from N-Allenylamides;100 1.12.5.3;3.1.5.3 Rhodium-Catalyzed Asymmetric [4 + 3] Cycloadditions between a-Diazo ß,.-Unsaturated Esters and Dienes;102 1.12.5.4;3.1.5.4 Palladium-Catalyzed [4 + 3] Cycloadditions of .-Methylene-d-valerolactones;105 1.12.5.5;3.1.5.5 Palladium-Catalyzed [4 + 3] Intramolecular Cycloadditions of Alkylidenecyclopropanes and Dienes;107 1.12.6;3.1.6 [5 + 2]-Cycloaddition Reactions;108 1.12.6.1;3.1.6.1 Rhodium-Catalyzed Asymmetric [5 + 2] Cyclo