The concept of selective estrogen receptor modulators (SERMs) has emerged recently in modern medicine. Two main features, the evidence of the wide expression of estrogen receptors in organs and systems and the growing information on the determinants of estrogen action, have allowed the envisioning of compounds with "a la carte" estrogenic profiles. The availability of substances performing as agonists wherever the estrogenic action is beneficial and as antagonists where it is not, is becoming less of a dream than of a closer reality. This book is an up-to-date review of the principal basic mechanisms and the clinical data integrating the actualcurrent knowledge on SERMs.

1;Preface;5 2;Contents;7 3;List of Contributors;14 4;Basic Area;17 4.1;Molecular Mechanisms of Estrogen Action in Target Tissues;18 4.2;Clinical Pharmacology of Selective Estrogen Receptor Modulators ( SERMs);63 4.3;Action of Selective Estrogen Receptor Modulators ( SERMs) Through the Classical Mechanism of Estrogen Action;84 4.4;Cellular and Molecular Basis for Acute Nongenomically Mediated Actions of SERMs;91 4.5;The Hypothalamus-Pituitary-Ovarian Axis as a Model System for the Study of SERM Effects: An Overview of Experimental and Clinical Studies;115 4.6;Pure Antiestrogens;152 5;Clinical Area;169 5.1;Physiological Regulation of Bone Metabolism and Estrogen Agonism;170 5.2;The Role of SERMs in the Treatment of Osteoporosis;196 5.3;Cardiovascular Disease and SERMs;216 5.4;SERMs and the Breast;248 5.5;Endometrial Effects of SERMs;280 5.6;Benign Gynecological Diseases and SERMs;300 5.7;Other Clinical Effects of SERMs;321 5.8;The Role of SERMs in theManagement of Postmenopausal Women;341 6;Subject Index;358

ISBN	9783540347422
Artikelnummer	9783540347422
Medientyp	E-Book - PDF
Copyrightjahr	2006
Verlag	Springer-Verlag
Umfang	357 Seiten
Sprache	Englisch
Kopierschutz	Digitales Wasserzeichen