In July, 1988, more than 300 scientists from 29 different countries gathered at Tiibingen, W. Germany, in order to spend 4 days discussing their favourite trace element, selenium. This meeting continued the good tradition of three previous meetings held in Corvallis/Oregon, 1976, in Lubbock/Texas, 1980, and in Beijing/China, in 1984. Incidentally, the University of Tiibingen provided a unique historical background for a Symposium devoted to recent advances in biochemistry, pharmacology, human nutrition and human health; here, the first independent depart ment of Physiological Chemistry in Germany was founded in 1845. Pro fessor H9Ppe-Seyler elucidated here the hemin structure and his student Friedrich Miescher discovered the nucleic acids. This book contains one-half of the oral or poster presentations which were selected before the meeting was held on the basis of a one page abstract. It is the reader who will have to decide whether this time consuming policy of quality assessment was warranted or not.

I Biochemistry of Selenoproteins and Selenium Compounds

The Regulation of Glutathione Peroxidase Gene Expression; Implication for Species Difference and the Effect of Dietary Selenium Manipulation
Regulation of Expression of Glutathione Peroxidase by Selenium
Studies on New Selenoproteins and Specific Selenium Target Tissues
Selenium-Containing Proteins in Plasma of Higher Primates
Involvement of a Selenoprotein in Glycine, Sarcosine, and Betaine Reduction by Eubacterium acidaminophilum
Dependence of Mouse Liver Phospholipid Hydroperoxide Glutathione Peroxidase on Dietary Selenium
Interaction of Heparin with a Selenoprotein in Human Plasma
Selenium-Independent Glutathione Peroxidase in Malaria Parasites
Synthesis of a Selenium Analogue of Neurospora crassa Metallothionein and Its Properties
Reactions of the Thioredoxin System with Selenium
Selenite-Induced Variation of Glutathione Peroxidase Activity in Mammalian Cells and Its Consequences for Cellular Radiation Resistance
Effects of Selenium Supplementation on Platelet Function as Assessed by Platelet Aggregation and Glutathione Peroxidase Activity
Role of Glutathione Peroxidase and ?-Tocopherol in Protecting Rat Erythrocytes Against tert-Butyl Hydroperoxide-Induced Hemolysis in Vitro
Active Oxygen Generation by the Reaction of Selenite with Reduced Glutathione in Vitro
Studies on Selenite-Induced DNA Fragmentation and the Role of Poly (ADP-Ribose) Polymerase in Selenite Toxicity
Involvement of Cellular Sulfhydryl Compounds in the Inhibition of DNA and RNA Synthesis by Selenite
II Influence of Selenium on the Metabolism of Animals and Man
Selenium-Dependent Metabolic Modulations in Mouse Liver
Selenium Deficiency and Thyroid Hormone Metabolism
Glutathione Metabolism as Affectedby Selenium Deficiency
Selenium Deficiency and the Metabolism of Ketone Bodies
Transport of Selenomethionine and Methionine Across the Intestinal Brush Border Membrane
Plasma Malondialdehyde and Exhaled Hydrocarbons: Are They Reliable Indicators of Lipid Peroxidation and Glutathione Peroxidase Activity?
Biochemical Studies on Selenium and Keshan Disease - The Oxidant Stress and Defence Capacity in Blood of Selenium-Deficient Children
Effect of Growth Phase on Deposition of Selenium (Se) in Tissues of Rats Fed Elevated Dietary Levels of Se as Either L-Selenomethionine or Sodium Selenate
Selenium Intake Induces Growth Retardation Through Reversible Growth Hormone and Irreversible Somatomedin C Suppression
Selenium in the Central Nervous System of the Rat After Exposure to 75-Se-L-Selenomethionine
Effect of Selenium on Adriamycin-Induced Cardiotoxicity in Mice
Effects of Selenium Deficiency on Mouse Articular Cartilage
Myocardial and Pancreatic Damage in Selenium Vitamin E Deficient Mice
III Biochemical Pharmacology of Selenium Compounds
Metabolism and Disposition of Ebselen
The Use of Highly Enriched 77Se in Metabolic Studies of Ebselen in Man - An NMR Investigation
Effect of Ebselen (PZ-51) in Liver Failure Induced by Propionibacterium acnes (P. Acnes)
Ebselen (PZ-51) Inhibits the Formation of Ischemic Brain Edema
Effects of Ebselen (PZ-51) on Experimental Cerebral Vasospasm
Ebselen, a Seleno-Organic Compound, Inhibits Leukocyte Aggregation and Reduces the Plasma Leukotriene B4 Level in Humans and Rats
Binding of Ebselen to Plasma Protein
Protection of Experimental Cobalt Cardiomyopathy in the Rat by Selenium Pretreatment
Correlation of Levels of Platinum and Selenium in Rats Treated with Cisplatin and Sodium Selenite
IVSelenium and Human Health
Progress in Establishing Human Nutritional Requirements and Dietary Recommendations for Selenium
Supplementation of a Population with Selenium - Reasons for Action and Initial Experience
Selenium Status and Cardiovascular Disease: Dutch Epidemiologic Data
Bioavailability of Selenium in a Selected Dutch Population
Studies of Human Maximal and Minimal Safe Intake and Requirement of Selenium
Are Germans Selenium-Deficient?
Blood Selenium Levels of Norwegians Compared to Their Se Intakes
The Intake of Selenium and Other Nutrients in a Group of Norwegian Rheumatics
Se Supplementation of Fertilizers Has Increased the Se Intake and Serum-Se Concentration of Finnish People
Selenium Status of Children and Adults in Northern Germany
Urinary Excretion of Selenium (Se) and Trimethylselenonium (TMSe) by NZ Women During Long Term Supplementation with Selenate or Selenomethionine (Semet)
Selenium (Se) and Glutathione Peroxidase (GSH-Px) in Blood Components of NZ Women During Long Term Supplementation with Selenate or Selenomethionine (Semet)
Comparison of Human Response to Low Doses of Inorganic and Organic Selenium
The Relativity Between Some Epidemiological Characteristics of Kaschin-Beck Disease and Selenium Deficiency
The Selenium and Phospholipid (Phosphatidylcholine) Deficiency and Low Temperature of Environment May be the Pathogenetic Basis of Kaschin-Beck Disease
Low Selenium State and Increased Erucic Acid in Children from Keshan Endemic Areas - A Pilot Study
Selenium in Children with Acute Leukaemia During Chemotherapy
Selenium Status and Age Effects
V Selenium and Malignant Growth
The Influence of Dietary Selenium on Colon, Pancreas, and Skin Tumorigenesis
Is Selenium Metabolism Necessary for ItsAnticarcinogenic Activity?
Low Serum Selenium Level and Elevated Risk of Lung Cancer
Study on the Relation of Se, Mn, Fe and Mo to Liver Cancer Mortality
Determination of Selenium Contents in Sera, Hair and Glutathione Peroxidase Activities in Whole Blood of Nasopharyngeal Carcinoma (NPC) Patients.