1 INTRODUCTION OF BIOIMAGING<br>1.1. Color<br>1.2 Colorful material<br>1.3 Light source of bioimaging<br>1.4 Subcellular imaging<br>1.5 Cell selective imaging<br>1.6 Tissue and organ imaging<br>1.7 Whole body imaging<br>1.8 Probes in bioimaging<br> <br>2. CHEMICAL SENSORS AND PROBES FOR BIOIMAGING<br>2.1 History of dyes in biological stains<br>2.2 Blood cell staining<br>2.3 Bacteria staining using Gram method<br>2.4 Fluorescent sensors and probes<br>2.5 Representative fluorescent compounds for bioimaging<br> <br>3. ORGANELLE SELECTIVE PROBES<br>3.1 Cell plasma membrane<br>3.2 Endosome and lysosome<br>3.3 Nucleus and DNA<br>3.4 Nucleolus and RNA<br>3.5 ER and Golgi body<br>3.6 Mitochondria<br>3.7 Lipid droplet<br>3.8 Peroxisome<br>3.9 Cytosol<br>3.10 Extracellular vesicle<br>3.11 Nonmembrane-bound condensate<br>3.12 Organelle probes in live cells and fixed cells<br>3.13 Modeling for organelle selective probes<br> <br>4. LIVE CELL SELECTIVE PROBES<br>4.1. Protein Oriented Live Cell Distinction (POLD)<br>4.2. Carbohydrate Oriented Live Cell Distinction (COLD)<br>4.3. Lipid Oriented Live Cell Distinction (LOLD)<br>4.4. Gating Oriented Live Cell Distinction (GOLD)<br>4.5. Metabolism Oriented Live Cell Distinction (MOLD)<br> <br>5. EX-VIVO TISSUE SELECTIVE PROBES<br>5.1 Immunohistochemistry<br>5.2 Tissue imaging with nucleic acid probes<br>5.3 Tissue imaging with small molecule probes<br>5.3.1 Pancreatic islet imaging<br>5.3.2 Neuronal tissue imaging<br>5.4 Organoid as model of tissue and organ<br> <br>6. IN-VIVO WHOLE-BODY IMAGING PROBES<br>6.1 ElaNIR for elastin imaging in mouse<br>6.2 Probes for exposed neuron in zebrafish embryo<br>6.3 NeuO for whole-body neuron imaging in zebrafish<br>6.4 LipidGreen for fatty tissue imaging in zebrafish<br>6.5 Blood vessel imaging in zebrafish<br>6.6 Probes for bone imaging<br>6.7 Probes for pancreatic islet imaging<br>6.8 Probes for eye imaging<br>6.9 Macrophage imaging in ischemia and inflammation<br> <br>7. IMAGING FOR BIOLOGICAL ENVIRONMENT AND FUNCTION<br>7.1 pH<br>7.2 Metal ions<br>7.3 Metabolites<br>7.4 Viscosity<br>7.5 Temperature<br>7.6 ROS and RNS<br> <br>8. IMAGING FOR DISEASE<br>8.1 Cancer imaging<br>8.2 Neurodegenerative disease imaging<br>8.3 Inflammation imaging<br>8.4 Diabetes imaging<br>8.5 Liver disease imaging<br>8.6 Aging<br>8.7 Theranostics<br> <br>9. NON-OPTICAL IMAGING PROBES<br>9.1 Ultrasound imaging probes<br>9.2 X-ray contrast agents<br>9.3 MRI contrast agents<br>9.4 SPECT probes<br>9.5 PET probes<br>9.6 Multimodality<br> <br>10. FLUORESCENCE IMAGING TECHNIQUES AND ANALYSIS METHODS<br>10.1 Multi-color imaging<br>10.2 Ratiometric measurement<br>10.3 Fluorescence lifetime imaging microscopy<br>10.4 Confocal fluorescence microscopy<br>10.5 Two photon excitation fluorescence imaging and harmonic generation<br>10.6 Selective plane illumination microscopy<br>10.7 Total internal reflection fluorescence microscopy<br>10.8 Super resolution imaging<br>10.9 Single molecule imaging<br>10.10 Photoactivation of caged molecule<br>10.11 Fluorescence recovery after photobleaching<br>10.12 Flow cytometry technique<br> <br>11. PERSPECTIVES FOR FUTURE PROBE DEVELOPMENT<br>11.1 Design of selective probes<br>11.2 Discovery of selective probes by screening<br>11.3 Future probe development