This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.

Drs. Rello, Lipman and Lisboa participate in several critical care meetings with lectures on sepsis, antibiotic treatment and organ dysfunction. Every year they organize a meeting in Tarragona, Spain on the management of sepsis.

From the contents:<br />Multiorgan dysfunction syndrome (MODS): What is new?

MODS scores. Which should I use?
Why guidelines require reform
PIRO concept and clinical failure
PIRO-based approach for sepsis in immunocompromised patients: What's different?
Intra-abdominal hypertension and MODS
Assessing renal dysfunction in septic patients
Monitoring myocardial dysfunction as part of sepsis management
The lung in multi-organ failure
Pathogens in severe sepsis. New paradigms for gram positive treatment
Pathogens in severe sepsis. New paradigms for fungi treatment
Importance of high creatinine clearance for antibacterial treatment in sepsis
How do I adjust antimicrobial daily dosage in patients with MODS? A pharmacist s contribution
Improving outcomes in sepsis and septic shock: Getting it right the first time.