Bone is a sex hormone-dependent organ, which has importantimplications for current therapeutic strategies in theprevention and possible treatment of bone loss in theelderly. This book contains the proceedings of the ScheringWorkshop on "Sex Steroids and Bone." The various chapters byleading experts give and overall view of current knowledgeon the control of bone hemostasis by sex steroids and newideas on how this controlcould be exerted. It was also ofparticular concern to integrate a general survey of in vivoexperimentation and histomorphometric evaluation of bonetissue. The organizers of the workshop and editors of thisvolume hope that it will contribute to a betterunderstanding of the role of sex steroids in bone and thuspave the way for a better experimental approach instudyingdrug effects on bone with the ultimate goal of improvingtherapy in bone diseases.

1 View of a Clinician: Sex Steroids and Osteoporosis

2 The Anabolic Action of Estrogen on Rat Bone
3 Progesterone and Its Role in Bone Remodelling
4 The Effect of Sex Steroids on Calciotropic Hormones In Vivo
5 Effects of Estrogen on Growth Factors in Bone
6 Estrogens, Cytokines, and Bone Metabolism
7 Sex Steroids and Prostaglandins in Bone Metabolism
8 Animal Models for Osteoporosis
9 The Rat as an Animal Model of Postmenopausal Bone Loss
10 Histomorphometric Studies of Bone Changes in Ovariectomized Rats and Their Prevention by Estrogen Replacement
11 Biochemical Assessment of Bone Metabolism in Rodents.