At the Sixth Wiggers Bernard Conference, a group of scientists from various fields discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. This meeting was dedicated to the presentation and discussion of positive and negative findings related to the use of NOS inhibitors, the issue of specific and non-specific inhibitors and the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field. With appropriate dosing and timing the use of NOS inhibitors seems to be beneficial at least in severe sepsis situations, but some inhibitors and overdosing can be potentially dangerous.

Inhibition of the Overproduction of Nitric Oxide in Septic Shock Using NG-Methyl-L-Arginine

Successful Administration of the NO Synthase Inhibitor 546C88 as a Delayed Continous Infusion in a Baboon Model of Septic Shock
Clinical Aspects of Nitric Oxide (NO?) Blockade with Pyridoxylated-Hemoglobin Polyoxyethylene Conjugate (PHP)
Norepinepherine Versus L-NMMA in Hyperdynamic Septic Shock
Roles for Induced Nitric Oxide in Endotoxic and Hemorrhagic Shock
Role of Nitric Oxide in the Regulation of Cardiovascular Performance: Clinical Implication for Sepsis and Congestive Heart Failure
Inducible NOS and Other Novel Mediators of Inflammation in Brain Trauma
Nitric Oxide and Leukocyte Adhesion: Experience with NO Inhibitors, NO Donors and iNOS-Deficient Mice
Cytokine Control of Nitric Oxide Production: Therapeutic Possibilities
Peroxynitrite: the Dark Side of Nitric Oxide-Effect of Mercaptoethylguanidine (MEG), a Combined Inhibitor of Inducible Nitric Oxide Synthase and Scavenger of Peroxynitrite in Shock, Inflammation, and Ischemia-Reperfusion Injury
Actions of Selective and Non-Selective Nitric Oxide Synthase Inhibitors on Multiple-Organ Microvascular Injury Provoked by Lipopolysaccharide
Inhibition of Nitric Oxide Synthases by the 4-Amino Analogue of Tetrahydrobiopterin
Effects of Nitric Oxide Inhibitors and Hemoglobin in Sepsis.